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Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress
The results of different human epidemiological datasets provided the impetus to introduce the now commonly accepted theory coined as ‘developmental programming’, whereby the presence of a stressor during gestation predisposes the growing fetus to develop diseases, such as metabolic dysfunction in la...
Autores principales: | , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Springer International Publishing
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658077/ https://www.ncbi.nlm.nih.gov/pubmed/32494846 http://dx.doi.org/10.1007/s00018-020-03566-z |
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author | Christoforou, Efthimia R. Sferruzzi-Perri, Amanda N. |
author_facet | Christoforou, Efthimia R. Sferruzzi-Perri, Amanda N. |
author_sort | Christoforou, Efthimia R. |
collection | PubMed |
description | The results of different human epidemiological datasets provided the impetus to introduce the now commonly accepted theory coined as ‘developmental programming’, whereby the presence of a stressor during gestation predisposes the growing fetus to develop diseases, such as metabolic dysfunction in later postnatal life. However, in a clinical setting, human lifespan and inaccessibility to tissue for analysis are major limitations to study the molecular mechanisms governing developmental programming. Subsequently, studies using animal models have proved indispensable to the identification of key molecular pathways and epigenetic mechanisms that are dysregulated in metabolic organs of the fetus and adult programmed due to an adverse gestational environment. Rodents such as mice and rats are the most used experimental animals in the study of developmental programming. This review summarises the molecular pathways and epigenetic mechanisms influencing alterations in metabolic tissues of rodent offspring exposed to in utero stress and subsequently programmed for metabolic dysfunction. By comparing molecular mechanisms in a variety of rodent models of in utero stress, we hope to summarise common themes and pathways governing later metabolic dysfunction in the offspring whilst identifying reasons for incongruencies between models so to inform future work. With the continued use and refinement of such models of developmental programming, the scientific community may gain the knowledge required for the targeted treatment of metabolic diseases that have intrauterine origins. |
format | Online Article Text |
id | pubmed-7658077 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Springer International Publishing |
record_format | MEDLINE/PubMed |
spelling | pubmed-76580772020-11-12 Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress Christoforou, Efthimia R. Sferruzzi-Perri, Amanda N. Cell Mol Life Sci Review The results of different human epidemiological datasets provided the impetus to introduce the now commonly accepted theory coined as ‘developmental programming’, whereby the presence of a stressor during gestation predisposes the growing fetus to develop diseases, such as metabolic dysfunction in later postnatal life. However, in a clinical setting, human lifespan and inaccessibility to tissue for analysis are major limitations to study the molecular mechanisms governing developmental programming. Subsequently, studies using animal models have proved indispensable to the identification of key molecular pathways and epigenetic mechanisms that are dysregulated in metabolic organs of the fetus and adult programmed due to an adverse gestational environment. Rodents such as mice and rats are the most used experimental animals in the study of developmental programming. This review summarises the molecular pathways and epigenetic mechanisms influencing alterations in metabolic tissues of rodent offspring exposed to in utero stress and subsequently programmed for metabolic dysfunction. By comparing molecular mechanisms in a variety of rodent models of in utero stress, we hope to summarise common themes and pathways governing later metabolic dysfunction in the offspring whilst identifying reasons for incongruencies between models so to inform future work. With the continued use and refinement of such models of developmental programming, the scientific community may gain the knowledge required for the targeted treatment of metabolic diseases that have intrauterine origins. Springer International Publishing 2020-06-03 2020 /pmc/articles/PMC7658077/ /pubmed/32494846 http://dx.doi.org/10.1007/s00018-020-03566-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. |
spellingShingle | Review Christoforou, Efthimia R. Sferruzzi-Perri, Amanda N. Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress |
title | Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress |
title_full | Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress |
title_fullStr | Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress |
title_full_unstemmed | Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress |
title_short | Molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress |
title_sort | molecular mechanisms governing offspring metabolic programming in rodent models of in utero stress |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658077/ https://www.ncbi.nlm.nih.gov/pubmed/32494846 http://dx.doi.org/10.1007/s00018-020-03566-z |
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