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A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine: “A gut feeling”

The human body is able to process and transport a complex variety of carbohydrates, unlocking their nutritional value as energy source or as important building block. The endogenous glycosyl hydrolases (glycosidases) and glycosyl transporter proteins located in the enterocytes of the small intestine...

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Autores principales: Elferink, Hidde, Bruekers, Jeroen P. J., Veeneman, Gerrit H., Boltje, Thomas J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer International Publishing 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658089/
https://www.ncbi.nlm.nih.gov/pubmed/32506169
http://dx.doi.org/10.1007/s00018-020-03564-1
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author Elferink, Hidde
Bruekers, Jeroen P. J.
Veeneman, Gerrit H.
Boltje, Thomas J.
author_facet Elferink, Hidde
Bruekers, Jeroen P. J.
Veeneman, Gerrit H.
Boltje, Thomas J.
author_sort Elferink, Hidde
collection PubMed
description The human body is able to process and transport a complex variety of carbohydrates, unlocking their nutritional value as energy source or as important building block. The endogenous glycosyl hydrolases (glycosidases) and glycosyl transporter proteins located in the enterocytes of the small intestine play a crucial role in this process and digest and/or transport nutritional sugars based on their structural features. It is for these reasons that glycosidases and glycosyl transporters are interesting therapeutic targets to combat sugar related diseases (such as diabetes) or to improve drug delivery. In this review we provide a detailed overview focused on the molecular structure of the substrates involved as a solid base to start from and to fuel research in the area of therapeutics and diagnostics.
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spelling pubmed-76580892020-11-13 A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine: “A gut feeling” Elferink, Hidde Bruekers, Jeroen P. J. Veeneman, Gerrit H. Boltje, Thomas J. Cell Mol Life Sci Review The human body is able to process and transport a complex variety of carbohydrates, unlocking their nutritional value as energy source or as important building block. The endogenous glycosyl hydrolases (glycosidases) and glycosyl transporter proteins located in the enterocytes of the small intestine play a crucial role in this process and digest and/or transport nutritional sugars based on their structural features. It is for these reasons that glycosidases and glycosyl transporters are interesting therapeutic targets to combat sugar related diseases (such as diabetes) or to improve drug delivery. In this review we provide a detailed overview focused on the molecular structure of the substrates involved as a solid base to start from and to fuel research in the area of therapeutics and diagnostics. Springer International Publishing 2020-06-06 2020 /pmc/articles/PMC7658089/ /pubmed/32506169 http://dx.doi.org/10.1007/s00018-020-03564-1 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Review
Elferink, Hidde
Bruekers, Jeroen P. J.
Veeneman, Gerrit H.
Boltje, Thomas J.
A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine: “A gut feeling”
title A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine: “A gut feeling”
title_full A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine: “A gut feeling”
title_fullStr A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine: “A gut feeling”
title_full_unstemmed A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine: “A gut feeling”
title_short A comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine: “A gut feeling”
title_sort comprehensive overview of substrate specificity of glycoside hydrolases and transporters in the small intestine: “a gut feeling”
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658089/
https://www.ncbi.nlm.nih.gov/pubmed/32506169
http://dx.doi.org/10.1007/s00018-020-03564-1
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