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Trends in Glucocerebrosides Research: A Systematic Review

Glucocerebrosides are sphingolipid components of cell membranes that intervene in numerous cell biological processes and signaling pathways and that deregulation is implicated in human diseases such as Gaucher disease and Parkinson's disease. In the present study, we conducted a systematic revi...

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Autores principales: Desplanque, Mazarine, Bonte, Marie-Amandine, Gressier, Bernard, Devos, David, Chartier-Harlin, Marie-Christine, Belarbi, Karim
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658098/
https://www.ncbi.nlm.nih.gov/pubmed/33192552
http://dx.doi.org/10.3389/fphys.2020.558090
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author Desplanque, Mazarine
Bonte, Marie-Amandine
Gressier, Bernard
Devos, David
Chartier-Harlin, Marie-Christine
Belarbi, Karim
author_facet Desplanque, Mazarine
Bonte, Marie-Amandine
Gressier, Bernard
Devos, David
Chartier-Harlin, Marie-Christine
Belarbi, Karim
author_sort Desplanque, Mazarine
collection PubMed
description Glucocerebrosides are sphingolipid components of cell membranes that intervene in numerous cell biological processes and signaling pathways and that deregulation is implicated in human diseases such as Gaucher disease and Parkinson's disease. In the present study, we conducted a systematic review using document co-citation analysis, clustering and visualization tools to explore the trends and knowledge structure of glucocerebrosides research as indexed in the Science Citation Index Expanded database (1956—present). A co-citation network of 5,324 publications related to glucocerebrosides was constructed. The analysis of emerging categories and keywords suggested a growth of research related to neurosciences over the last decade. We identified ten major areas of research (e.g., clusters) that developed over time, from the oldest (i.e., on glucocerebrosidase protein or molecular analysis of the GBA gene) to the most recent ones (i.e., on drug resistance in cancer, pharmacological chaperones, or Parkinson's disease). We provided for each cluster the most cited publications and a description of their intellectual content. We moreover identified emerging trends in glucocerebrosides research by detecting the surges in the rate of publication citations in the most recent years. In conclusion, this study helps to apprehend the most significant lines of research on glucocerebrosides. This should strengthen the connections between scientific communities studying glycosphingolipids to facilitate advances, especially for the most recent researches on cancer drug resistance and Parkinson's disease.
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spelling pubmed-76580982020-11-13 Trends in Glucocerebrosides Research: A Systematic Review Desplanque, Mazarine Bonte, Marie-Amandine Gressier, Bernard Devos, David Chartier-Harlin, Marie-Christine Belarbi, Karim Front Physiol Physiology Glucocerebrosides are sphingolipid components of cell membranes that intervene in numerous cell biological processes and signaling pathways and that deregulation is implicated in human diseases such as Gaucher disease and Parkinson's disease. In the present study, we conducted a systematic review using document co-citation analysis, clustering and visualization tools to explore the trends and knowledge structure of glucocerebrosides research as indexed in the Science Citation Index Expanded database (1956—present). A co-citation network of 5,324 publications related to glucocerebrosides was constructed. The analysis of emerging categories and keywords suggested a growth of research related to neurosciences over the last decade. We identified ten major areas of research (e.g., clusters) that developed over time, from the oldest (i.e., on glucocerebrosidase protein or molecular analysis of the GBA gene) to the most recent ones (i.e., on drug resistance in cancer, pharmacological chaperones, or Parkinson's disease). We provided for each cluster the most cited publications and a description of their intellectual content. We moreover identified emerging trends in glucocerebrosides research by detecting the surges in the rate of publication citations in the most recent years. In conclusion, this study helps to apprehend the most significant lines of research on glucocerebrosides. This should strengthen the connections between scientific communities studying glycosphingolipids to facilitate advances, especially for the most recent researches on cancer drug resistance and Parkinson's disease. Frontiers Media S.A. 2020-10-29 /pmc/articles/PMC7658098/ /pubmed/33192552 http://dx.doi.org/10.3389/fphys.2020.558090 Text en Copyright © 2020 Desplanque, Bonte, Gressier, Devos, Chartier-Harlin and Belarbi. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Physiology
Desplanque, Mazarine
Bonte, Marie-Amandine
Gressier, Bernard
Devos, David
Chartier-Harlin, Marie-Christine
Belarbi, Karim
Trends in Glucocerebrosides Research: A Systematic Review
title Trends in Glucocerebrosides Research: A Systematic Review
title_full Trends in Glucocerebrosides Research: A Systematic Review
title_fullStr Trends in Glucocerebrosides Research: A Systematic Review
title_full_unstemmed Trends in Glucocerebrosides Research: A Systematic Review
title_short Trends in Glucocerebrosides Research: A Systematic Review
title_sort trends in glucocerebrosides research: a systematic review
topic Physiology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658098/
https://www.ncbi.nlm.nih.gov/pubmed/33192552
http://dx.doi.org/10.3389/fphys.2020.558090
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