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PPARα agonist and metformin co-treatment ameliorates NASH in mice induced by a choline-deficient, amino acid-defined diet with 45% fat

We explored the beneficial effects of GW7647, a peroxisome proliferator activated receptor α (PPARα) agonist, and metformin, an anti-diabetic drug on an advanced nonalcoholic steatohepatitis (NASH) model in rodents and investigated the possible mechanisms involved. Mice were fed control chow or a ch...

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Detalles Bibliográficos
Autores principales:	Okishio, Shinya, Yamaguchi, Kanji, Ishiba, Hiroshi, Tochiki, Nozomi, Yano, Kota, Takahashi, Aya, Kataoka, Seita, Okuda, Keiichiroh, Seko, Yuya, Liu, Yu, Fujii, Hideki, Takahashi, Daiki, Ito, Yusuke, Kamon, Junji, Umemura, Atsushi, Moriguchi, Michihisa, Yasui, Kohichiroh, Okanoue, Takeshi, Itoh, Yoshito
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658250/ https://www.ncbi.nlm.nih.gov/pubmed/33177546 http://dx.doi.org/10.1038/s41598-020-75805-z

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