Effects of CYP46A1 Inhibition on Long-Term-Depression in Hippocampal Slices ex vivo and 24S-Hydroxycholesterol Levels in Mice in vivo

The manipulation of cholesterol and its metabolites has been hypothesized to be therapeutically beneficial for mood disorders, neurodegenerative disorders, and epilepsies. A major regulator of cholesterol clearance and turnover in the central nervous system is CYP46A1, a brain enriched enzyme respon...

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Detalles Bibliográficos
Autores principales: Popiolek, Michael, Izumi, Yukitoshi, Hopper, Allen T., Dai, Jing, Miller, Silke, Shu, Hong-Jin, Zorumski, Charles F., Mennerick, Steven
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Neuroscience
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658267/
https://www.ncbi.nlm.nih.gov/pubmed/33192294
http://dx.doi.org/10.3389/fnmol.2020.568641

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658267/
https://www.ncbi.nlm.nih.gov/pubmed/33192294
http://dx.doi.org/10.3389/fnmol.2020.568641

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