Protein quality control of cell stemness

Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued proliferation and differentiation of stem cells require a high rate of translation; therefor...

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Detalles Bibliográficos
Autores principales: Yan, Pengze, Ren, Jie, Zhang, Weiqi, Qu, Jing, Liu, Guang-Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Singapore 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658286/
https://www.ncbi.nlm.nih.gov/pubmed/33179756
http://dx.doi.org/10.1186/s13619-020-00064-2
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author Yan, Pengze
Ren, Jie
Zhang, Weiqi
Qu, Jing
Liu, Guang-Hui
author_facet Yan, Pengze
Ren, Jie
Zhang, Weiqi
Qu, Jing
Liu, Guang-Hui
author_sort Yan, Pengze
collection PubMed
description Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued proliferation and differentiation of stem cells require a high rate of translation; therefore, accurate PQC systems are essential to maintain stem cell function. Growing evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem cells. This review focuses on current knowledge regarding the components of the proteostasis network in stem cells, and the importance of proteostasis in maintaining stem cell identity and regenerative functions. A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases.
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spelling pubmed-76582862020-11-17 Protein quality control of cell stemness Yan, Pengze Ren, Jie Zhang, Weiqi Qu, Jing Liu, Guang-Hui Cell Regen Review Protein quality control (PQC) systems play essential roles in the recognition, refolding and clearance of aberrant proteins, thus ensuring cellular protein homeostasis, or proteostasis. Especially, continued proliferation and differentiation of stem cells require a high rate of translation; therefore, accurate PQC systems are essential to maintain stem cell function. Growing evidence suggested crucial roles of PQC systems in regulating the stemness and differentiation of stem cells. This review focuses on current knowledge regarding the components of the proteostasis network in stem cells, and the importance of proteostasis in maintaining stem cell identity and regenerative functions. A complete understanding of this process might uncover potential applications in aging intervention and aging-related diseases. Springer Singapore 2020-11-12 /pmc/articles/PMC7658286/ /pubmed/33179756 http://dx.doi.org/10.1186/s13619-020-00064-2 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Review
Yan, Pengze
Ren, Jie
Zhang, Weiqi
Qu, Jing
Liu, Guang-Hui
Protein quality control of cell stemness
title Protein quality control of cell stemness
title_full Protein quality control of cell stemness
title_fullStr Protein quality control of cell stemness
title_full_unstemmed Protein quality control of cell stemness
title_short Protein quality control of cell stemness
title_sort protein quality control of cell stemness
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658286/
https://www.ncbi.nlm.nih.gov/pubmed/33179756
http://dx.doi.org/10.1186/s13619-020-00064-2
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