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Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures
Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific interests due to their potential applications in disease diagnosis,...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Frontiers Media S.A.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658299/ https://www.ncbi.nlm.nih.gov/pubmed/33195088 http://dx.doi.org/10.3389/fchem.2020.587975 |
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author | Zhang, Wenbo Mo, Shanshan Liu, Mingwei Liu, Lei Yu, Lanlan Wang, Chenxuan |
author_facet | Zhang, Wenbo Mo, Shanshan Liu, Mingwei Liu, Lei Yu, Lanlan Wang, Chenxuan |
author_sort | Zhang, Wenbo |
collection | PubMed |
description | Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific interests due to their potential applications in disease diagnosis, illness treatment, biomechanics, bio-optics and bio-electronics, etc. This review outlines recent efforts directed to the creation of structurally defined protein assemblies including one-dimensional (1D) strings/rings/tubules, two-dimensional (2D) planar sheets and three-dimensional (3D) polyhedral scaffolds. We elucidate various innovative strategies for manipulating proteins to self-assemble into desired architectures. The emergent applications of protein assemblies as versatile platforms in medicine and material science with improved performances have also been discussed. |
format | Online Article Text |
id | pubmed-7658299 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Frontiers Media S.A. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76582992020-11-13 Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures Zhang, Wenbo Mo, Shanshan Liu, Mingwei Liu, Lei Yu, Lanlan Wang, Chenxuan Front Chem Chemistry Diverse natural/artificial proteins have been used as building blocks to construct a variety of well-ordered nanoscale structures over the past couple of decades. Sophisticated protein self-assemblies have attracted great scientific interests due to their potential applications in disease diagnosis, illness treatment, biomechanics, bio-optics and bio-electronics, etc. This review outlines recent efforts directed to the creation of structurally defined protein assemblies including one-dimensional (1D) strings/rings/tubules, two-dimensional (2D) planar sheets and three-dimensional (3D) polyhedral scaffolds. We elucidate various innovative strategies for manipulating proteins to self-assemble into desired architectures. The emergent applications of protein assemblies as versatile platforms in medicine and material science with improved performances have also been discussed. Frontiers Media S.A. 2020-10-29 /pmc/articles/PMC7658299/ /pubmed/33195088 http://dx.doi.org/10.3389/fchem.2020.587975 Text en Copyright © 2020 Zhang, Mo, Liu, Liu, Yu and Wang. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms. |
spellingShingle | Chemistry Zhang, Wenbo Mo, Shanshan Liu, Mingwei Liu, Lei Yu, Lanlan Wang, Chenxuan Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
title | Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
title_full | Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
title_fullStr | Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
title_full_unstemmed | Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
title_short | Rationally Designed Protein Building Blocks for Programmable Hierarchical Architectures |
title_sort | rationally designed protein building blocks for programmable hierarchical architectures |
topic | Chemistry |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658299/ https://www.ncbi.nlm.nih.gov/pubmed/33195088 http://dx.doi.org/10.3389/fchem.2020.587975 |
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