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Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals

Objective: Betel quid dependency (BQD) is characterized by functional and structural brain alterations. Trait impulsivity may influence substance dependence by impacting its neurobiological underpinnings in the frontostriatal circuit. However, little is known about the trait impulsivity and its neur...

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Autores principales: Qian, Zhaoxin, Liu, Shaohui, Zhu, Xueling, Kong, Lingyu, Liu, Neng, Wang, Dongcui, Jiang, Canhua, Zhan, Zhongyuan, Yuan, Fulai
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658367/
https://www.ncbi.nlm.nih.gov/pubmed/33192412
http://dx.doi.org/10.3389/fnhum.2020.578913
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author Qian, Zhaoxin
Liu, Shaohui
Zhu, Xueling
Kong, Lingyu
Liu, Neng
Wang, Dongcui
Jiang, Canhua
Zhan, Zhongyuan
Yuan, Fulai
author_facet Qian, Zhaoxin
Liu, Shaohui
Zhu, Xueling
Kong, Lingyu
Liu, Neng
Wang, Dongcui
Jiang, Canhua
Zhan, Zhongyuan
Yuan, Fulai
author_sort Qian, Zhaoxin
collection PubMed
description Objective: Betel quid dependency (BQD) is characterized by functional and structural brain alterations. Trait impulsivity may influence substance dependence by impacting its neurobiological underpinnings in the frontostriatal circuit. However, little is known about the trait impulsivity and its neural correlates in individuals with BQD. Methods: Forty-eight participants with BQD and 22 normal controls (NCs) were recruited and scanned on a 3T MRI scanner. Barratt impulsiveness scale (BIS) was used to measure trait impulsivity: motor, attention, and no plan impulsivity. We used voxel-based morphometry (VBM) to assess the relationship between trait impulsivity and gray matter volumes. The relevant clusters identified were served as regions of interest (ROI) seeds. The whole-volume psycho-physiological interactions (PPI) analysis was used to investigate the changes of functional connectivity related to ROI seeds in the cue-reactivity task condition (BQ and control images). Results: Behaviorally, the BQD group showed significantly higher trait impulsivity including motor and no plan impulsivity than the NCs group. VBM analyses showed that motor impulsivity was negatively associated with gray matter volume of right caudate in the whole sample. No difference in gray matter volume between the two groups was observed. PPI analyses showed that there was a significantly decreased functional connectivity between the right caudate and right dorsolateral prefrontal cortex (DLPFC) when watching BQ related images than control images in individuals with BQD. Furthermore, functional connectivity between the right caudate and right DLPFC was negatively correlated with BQ dependency scores. Conclusions: Our study demonstrated the structural basis of trait impulsivity in the caudate and provided evidence for abnormal interactions within frontostriatal circuitsin individuals with BQD, which may provide insight into the selection of potential novel therapeutic targets for the treatment of BQ dependency.
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spelling pubmed-76583672020-11-13 Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals Qian, Zhaoxin Liu, Shaohui Zhu, Xueling Kong, Lingyu Liu, Neng Wang, Dongcui Jiang, Canhua Zhan, Zhongyuan Yuan, Fulai Front Hum Neurosci Human Neuroscience Objective: Betel quid dependency (BQD) is characterized by functional and structural brain alterations. Trait impulsivity may influence substance dependence by impacting its neurobiological underpinnings in the frontostriatal circuit. However, little is known about the trait impulsivity and its neural correlates in individuals with BQD. Methods: Forty-eight participants with BQD and 22 normal controls (NCs) were recruited and scanned on a 3T MRI scanner. Barratt impulsiveness scale (BIS) was used to measure trait impulsivity: motor, attention, and no plan impulsivity. We used voxel-based morphometry (VBM) to assess the relationship between trait impulsivity and gray matter volumes. The relevant clusters identified were served as regions of interest (ROI) seeds. The whole-volume psycho-physiological interactions (PPI) analysis was used to investigate the changes of functional connectivity related to ROI seeds in the cue-reactivity task condition (BQ and control images). Results: Behaviorally, the BQD group showed significantly higher trait impulsivity including motor and no plan impulsivity than the NCs group. VBM analyses showed that motor impulsivity was negatively associated with gray matter volume of right caudate in the whole sample. No difference in gray matter volume between the two groups was observed. PPI analyses showed that there was a significantly decreased functional connectivity between the right caudate and right dorsolateral prefrontal cortex (DLPFC) when watching BQ related images than control images in individuals with BQD. Furthermore, functional connectivity between the right caudate and right DLPFC was negatively correlated with BQ dependency scores. Conclusions: Our study demonstrated the structural basis of trait impulsivity in the caudate and provided evidence for abnormal interactions within frontostriatal circuitsin individuals with BQD, which may provide insight into the selection of potential novel therapeutic targets for the treatment of BQ dependency. Frontiers Media S.A. 2020-10-29 /pmc/articles/PMC7658367/ /pubmed/33192412 http://dx.doi.org/10.3389/fnhum.2020.578913 Text en Copyright © 2020 Qian, Liu, Zhu, Kong, Liu, Wang, Jiang, Zhan and Yuan. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Human Neuroscience
Qian, Zhaoxin
Liu, Shaohui
Zhu, Xueling
Kong, Lingyu
Liu, Neng
Wang, Dongcui
Jiang, Canhua
Zhan, Zhongyuan
Yuan, Fulai
Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals
title Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals
title_full Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals
title_fullStr Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals
title_full_unstemmed Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals
title_short Higher Trait Impulsivity and Altered Frontostriatal Connectivity in Betel-Quid Dependent Individuals
title_sort higher trait impulsivity and altered frontostriatal connectivity in betel-quid dependent individuals
topic Human Neuroscience
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658367/
https://www.ncbi.nlm.nih.gov/pubmed/33192412
http://dx.doi.org/10.3389/fnhum.2020.578913
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