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Metachronous double primary neuroendocrine tumors in larynx and lung: a case report

When a patient harbors two or more neuroendocrine tumors (NETs), it can be difficult to determine whether they are double primary tumors or metastases. A 60-year-old man complained of voice change lasting 1 month. On physical examination and imaging, a 1.8-cm mass was observed in his epiglottis, and...

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Autores principales: Song, In Hye, Lee, Youn Soo, Sun, Dong-Il, Hong, Yong-Kil, Lee, Kyo-Young
Formato: Online Artículo Texto
Lenguaje:English
Publicado: SAGE Publications 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658525/
https://www.ncbi.nlm.nih.gov/pubmed/33167723
http://dx.doi.org/10.1177/0300060520962928
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author Song, In Hye
Lee, Youn Soo
Sun, Dong-Il
Hong, Yong-Kil
Lee, Kyo-Young
author_facet Song, In Hye
Lee, Youn Soo
Sun, Dong-Il
Hong, Yong-Kil
Lee, Kyo-Young
author_sort Song, In Hye
collection PubMed
description When a patient harbors two or more neuroendocrine tumors (NETs), it can be difficult to determine whether they are double primary tumors or metastases. A 60-year-old man complained of voice change lasting 1 month. On physical examination and imaging, a 1.8-cm mass was observed in his epiglottis, and a laser epiglottectomy was performed. Upon microscopic examination, the tumor consisted of medium-sized ovoid or short spindle cells. Immunohistochemical staining of the tumor cells was positive for synaptophysin, chromogranin, and calcitonin but negative for CD56; the Ki-67 proliferation index was approximately 5%. The patient was diagnosed with atypical carcinoid tumor. In 2015, a hypermetabolic endobronchial tumor was identified in the left lower lobe by positron emission tomography-computed tomography. Bronchoscopic biopsy revealed palisading large tumor cells with high nuclear-cytoplasmic ratio, frequent mitoses, and necrosis. The tumor cells were positive for CD56 and negative for cytokeratin-7, thyroid transcription factor-1, P40, synaptophysin, chromogranin, and calcitonin; the Ki-67 proliferation index was approximately 90%. Overall histologic findings were consistent with large cell neuroendocrine carcinoma rather than metastatic atypical carcinoid tumor. Detailed clinical and pathological review are essential to differentiate between metastatic NET and double primary NETs and, therefore, to provide the best management of the patient.
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spelling pubmed-76585252020-11-20 Metachronous double primary neuroendocrine tumors in larynx and lung: a case report Song, In Hye Lee, Youn Soo Sun, Dong-Il Hong, Yong-Kil Lee, Kyo-Young J Int Med Res Case Report When a patient harbors two or more neuroendocrine tumors (NETs), it can be difficult to determine whether they are double primary tumors or metastases. A 60-year-old man complained of voice change lasting 1 month. On physical examination and imaging, a 1.8-cm mass was observed in his epiglottis, and a laser epiglottectomy was performed. Upon microscopic examination, the tumor consisted of medium-sized ovoid or short spindle cells. Immunohistochemical staining of the tumor cells was positive for synaptophysin, chromogranin, and calcitonin but negative for CD56; the Ki-67 proliferation index was approximately 5%. The patient was diagnosed with atypical carcinoid tumor. In 2015, a hypermetabolic endobronchial tumor was identified in the left lower lobe by positron emission tomography-computed tomography. Bronchoscopic biopsy revealed palisading large tumor cells with high nuclear-cytoplasmic ratio, frequent mitoses, and necrosis. The tumor cells were positive for CD56 and negative for cytokeratin-7, thyroid transcription factor-1, P40, synaptophysin, chromogranin, and calcitonin; the Ki-67 proliferation index was approximately 90%. Overall histologic findings were consistent with large cell neuroendocrine carcinoma rather than metastatic atypical carcinoid tumor. Detailed clinical and pathological review are essential to differentiate between metastatic NET and double primary NETs and, therefore, to provide the best management of the patient. SAGE Publications 2020-11-09 /pmc/articles/PMC7658525/ /pubmed/33167723 http://dx.doi.org/10.1177/0300060520962928 Text en © The Author(s) 2020 https://creativecommons.org/licenses/by-nc/4.0/ Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).
spellingShingle Case Report
Song, In Hye
Lee, Youn Soo
Sun, Dong-Il
Hong, Yong-Kil
Lee, Kyo-Young
Metachronous double primary neuroendocrine tumors in larynx and lung: a case report
title Metachronous double primary neuroendocrine tumors in larynx and lung: a case report
title_full Metachronous double primary neuroendocrine tumors in larynx and lung: a case report
title_fullStr Metachronous double primary neuroendocrine tumors in larynx and lung: a case report
title_full_unstemmed Metachronous double primary neuroendocrine tumors in larynx and lung: a case report
title_short Metachronous double primary neuroendocrine tumors in larynx and lung: a case report
title_sort metachronous double primary neuroendocrine tumors in larynx and lung: a case report
topic Case Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658525/
https://www.ncbi.nlm.nih.gov/pubmed/33167723
http://dx.doi.org/10.1177/0300060520962928
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