FAMSi: A Synthetic Biology Approach to the Fast Assembly of Multiplex siRNAs for Silencing Gene Expression in Mammalian Cells

RNA interference (RNAi) is mediated by an ∼21-nt double-stranded small interfering RNA (siRNA) and shows great promise in delineating gene functions and in developing therapeutics for human diseases. However, effective gene silencing usually requires the delivery of multiple siRNAs for a given gene,...

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Detalles Bibliográficos
Autores principales: He, Fang, Ni, Na, Zeng, Zongyue, Wu, Di, Feng, Yixiao, Li, Alexander J., Luu, Benjamin, Li, Alissa F., Qin, Kevin, Wang, Eric, Wang, Xi, Wu, Xiaoxing, Luo, Huaxiu, Zhang, Jing, Zhang, Meng, Mao, Yukun, Pakvasa, Mikhail, Wagstaff, William, Zhang, Yongtao, Niu, Changchun, Wang, Hao, Huang, Linjuan, Shi, Deyao, Liu, Qing, Zhao, Xia, Fu, Kai, Reid, Russell R., Wolf, Jennifer Moriatis, Lee, Michael J., Hynes, Kelly, Strelzow, Jason, El Dafrawy, Mostafa, Gan, Hua, He, Tong-Chuan, Fan, Jiaming
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society of Gene & Cell Therapy 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658575/
https://www.ncbi.nlm.nih.gov/pubmed/33230483
http://dx.doi.org/10.1016/j.omtn.2020.10.007

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