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The Role of Contactin 1 in Cancers: What We Know So Far

Cancers are among the difficult-to-treat diseases despite advances in diagnosis and treatment. Although newer effective targets remain to be discovered, targeted therapy has emerged as a promising field. In the last decade, contactin 1 (CNTN1) has surfaced as an important cancer-related molecule. CN...

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Autores principales: Liang, Yumei, Ma, Cui, Li, Fengjuan, Nie, Guanhua, Zhang, Haining
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658624/
https://www.ncbi.nlm.nih.gov/pubmed/33194679
http://dx.doi.org/10.3389/fonc.2020.574208
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author Liang, Yumei
Ma, Cui
Li, Fengjuan
Nie, Guanhua
Zhang, Haining
author_facet Liang, Yumei
Ma, Cui
Li, Fengjuan
Nie, Guanhua
Zhang, Haining
author_sort Liang, Yumei
collection PubMed
description Cancers are among the difficult-to-treat diseases despite advances in diagnosis and treatment. Although newer effective targets remain to be discovered, targeted therapy has emerged as a promising field. In the last decade, contactin 1 (CNTN1) has surfaced as an important cancer-related molecule. CNTN1 is a neuronal membrane glycoprotein, which, if overexpressed, is found in different cancer cell lines, cancer tissues, and transgenic mice. It is positively associated with lymphatic invasion, metastasis, late TNM stage, and a short overall survival time. However, the role of CNTN1 in cancer cell proliferation remains unclear. In addition, CNTN1 is involved in cancer cell invasion, migration, metastasis, and chemoresistance by promoting epithelial-mesenchymal transition and mediating several signal transduction pathways. Several studies suggest CNTN1 as a new therapeutic target for cancers. This review aims to summarize the research developments on CNTN1 in various cancers, to establish its role in epithelial-mesenchymal transition and signal transduction pathways, and to identify promising areas for further investigation.
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spelling pubmed-76586242020-11-13 The Role of Contactin 1 in Cancers: What We Know So Far Liang, Yumei Ma, Cui Li, Fengjuan Nie, Guanhua Zhang, Haining Front Oncol Oncology Cancers are among the difficult-to-treat diseases despite advances in diagnosis and treatment. Although newer effective targets remain to be discovered, targeted therapy has emerged as a promising field. In the last decade, contactin 1 (CNTN1) has surfaced as an important cancer-related molecule. CNTN1 is a neuronal membrane glycoprotein, which, if overexpressed, is found in different cancer cell lines, cancer tissues, and transgenic mice. It is positively associated with lymphatic invasion, metastasis, late TNM stage, and a short overall survival time. However, the role of CNTN1 in cancer cell proliferation remains unclear. In addition, CNTN1 is involved in cancer cell invasion, migration, metastasis, and chemoresistance by promoting epithelial-mesenchymal transition and mediating several signal transduction pathways. Several studies suggest CNTN1 as a new therapeutic target for cancers. This review aims to summarize the research developments on CNTN1 in various cancers, to establish its role in epithelial-mesenchymal transition and signal transduction pathways, and to identify promising areas for further investigation. Frontiers Media S.A. 2020-10-29 /pmc/articles/PMC7658624/ /pubmed/33194679 http://dx.doi.org/10.3389/fonc.2020.574208 Text en Copyright © 2020 Liang, Ma, Li, Nie and Zhang http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Oncology
Liang, Yumei
Ma, Cui
Li, Fengjuan
Nie, Guanhua
Zhang, Haining
The Role of Contactin 1 in Cancers: What We Know So Far
title The Role of Contactin 1 in Cancers: What We Know So Far
title_full The Role of Contactin 1 in Cancers: What We Know So Far
title_fullStr The Role of Contactin 1 in Cancers: What We Know So Far
title_full_unstemmed The Role of Contactin 1 in Cancers: What We Know So Far
title_short The Role of Contactin 1 in Cancers: What We Know So Far
title_sort role of contactin 1 in cancers: what we know so far
topic Oncology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658624/
https://www.ncbi.nlm.nih.gov/pubmed/33194679
http://dx.doi.org/10.3389/fonc.2020.574208
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