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Analysis of Approaches to Anti-tuberculosis Compounds
[Image: see text] Mycobacterium tuberculosis (Mtb) remains a deadly pathogen two decades after the announcement of tuberculosis (TB) as a global health emergency by the World Health Organization. Medicinal chemistry efforts to synthesize potential drugs to shorten TB treatments have not always been...
| Autores principales: | , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
American Chemical Society
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658936/ https://www.ncbi.nlm.nih.gov/pubmed/33195903 http://dx.doi.org/10.1021/acsomega.0c03177 |
| _version_ | 1783608753580408832 |
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| author | Motamen, Sara Quinn, Ronald J. |
| author_facet | Motamen, Sara Quinn, Ronald J. |
| author_sort | Motamen, Sara |
| collection | PubMed |
| description | [Image: see text] Mycobacterium tuberculosis (Mtb) remains a deadly pathogen two decades after the announcement of tuberculosis (TB) as a global health emergency by the World Health Organization. Medicinal chemistry efforts to synthesize potential drugs to shorten TB treatments have not always been successful. Here, we analyze physiochemical properties of 39 TB drugs and 1271 synthetic compounds reported in 40 publications from 2006 to early 2020. We also propose a new TB space of physiochemical properties that may provide more appropriate guidelines for design of anti-TB drugs. |
| format | Online Article Text |
| id | pubmed-7658936 |
| institution | National Center for Biotechnology Information |
| language | English |
| publishDate | 2020 |
| publisher | American Chemical Society |
| record_format | MEDLINE/PubMed |
| spelling | pubmed-76589362020-11-13 Analysis of Approaches to Anti-tuberculosis Compounds Motamen, Sara Quinn, Ronald J. ACS Omega [Image: see text] Mycobacterium tuberculosis (Mtb) remains a deadly pathogen two decades after the announcement of tuberculosis (TB) as a global health emergency by the World Health Organization. Medicinal chemistry efforts to synthesize potential drugs to shorten TB treatments have not always been successful. Here, we analyze physiochemical properties of 39 TB drugs and 1271 synthetic compounds reported in 40 publications from 2006 to early 2020. We also propose a new TB space of physiochemical properties that may provide more appropriate guidelines for design of anti-TB drugs. American Chemical Society 2020-10-27 /pmc/articles/PMC7658936/ /pubmed/33195903 http://dx.doi.org/10.1021/acsomega.0c03177 Text en © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited. |
| spellingShingle | Motamen, Sara Quinn, Ronald J. Analysis of Approaches to Anti-tuberculosis Compounds |
| title | Analysis of Approaches to Anti-tuberculosis Compounds |
| title_full | Analysis of Approaches to Anti-tuberculosis Compounds |
| title_fullStr | Analysis of Approaches to Anti-tuberculosis Compounds |
| title_full_unstemmed | Analysis of Approaches to Anti-tuberculosis Compounds |
| title_short | Analysis of Approaches to Anti-tuberculosis Compounds |
| title_sort | analysis of approaches to anti-tuberculosis compounds |
| url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658936/ https://www.ncbi.nlm.nih.gov/pubmed/33195903 http://dx.doi.org/10.1021/acsomega.0c03177 |
| work_keys_str_mv | AT motamensara analysisofapproachestoantituberculosiscompounds AT quinnronaldj analysisofapproachestoantituberculosiscompounds |