Cargando…

The mechanism of m(6)A methyltransferase METTL3-mediated autophagy in reversing gefitinib resistance in NSCLC cells by β-elemene

N(6)-methyladenosine (m(6)A) modification can alter gene expression by regulating RNA splicing, stability, translocation, and translation. Emerging evidence shows that m(6)A modification plays an important role in cancer development and progression, including cell proliferation, migration and invasi...

Descripción completa

Detalles Bibliográficos
Autores principales:	Liu, Shuiping, Li, Qiujie, Li, Guohua, Zhang, Qin, Zhuo, Lvjia, Han, Xuemeng, Zhang, Mingming, Chen, Xiaying, Pan, Ting, Yan, Lili, Jin, Ting, Wang, Jianjun, Lv, Qun, Sui, Xinbing, Xie, Tian
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7658972/ https://www.ncbi.nlm.nih.gov/pubmed/33177491 http://dx.doi.org/10.1038/s41419-020-03148-8

Ejemplares similares

Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes
por: Zhai, Bingtao, et al.
Publicado: (2020)

An ATF(24) peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment
por: Zhai, Bingtao, et al.
Publicado: (2020)

β-Elemene Reverses the Resistance of p53-Deficient Colorectal Cancer Cells to 5-Fluorouracil by Inducing Pro-death Autophagy and Cyclin D3-Dependent Cycle Arrest
por: Zhang, Ruonan, et al.
Publicado: (2020)

Biological functions of m(6)A methyltransferases
por: Gu, Jianzhong, et al.
Publicado: (2021)

Combinative treatment of β-elemene and cetuximab is sensitive to KRAS mutant colorectal cancer cells by inducing ferroptosis and inhibiting epithelial-mesenchymal transformation
por: Chen, Peng, et al.
Publicado: (2020)

Efficacy and safety of elemene combined with chemotherapy in advanced gastric cancer: A Meta-analysis
por: Liu, Ying, et al.
Publicado: (2020)

PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death
por: Liu, Shuiping, et al.
Publicado: (2019)

Erianin, a novel dibenzyl compound in Dendrobium extract, inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis
por: Chen, Peng, et al.
Publicado: (2020)

Drug delivery systems for elemene, its main active ingredient β-elemene, and its derivatives in cancer therapy
por: Zhai, Bingtao, et al.
Publicado: (2018)

FBP1 induced by β‐elemene enhances the sensitivity of gefitinib in lung cancer
por: Li, Jian, et al.
Publicado: (2022)

p53/PCDH17/Beclin-1 Proteins as Prognostic Predictors for Urinary Bladder Cancer
por: Chen, Liuxi, et al.
Publicado: (2019)

RSL3 Drives Ferroptosis Through GPX4 Inactivation and ROS Production in Colorectal Cancer
por: Sui, Xinbing, et al.
Publicado: (2018)

β-Elemene Synergizes With Gefitinib to Inhibit Stem-Like Phenotypes and Progression of Lung Cancer via Down-Regulating EZH2
por: Cheng, Haibo, et al.
Publicado: (2018)

RNA methyltransferase METTL3 induces intrinsic resistance to gefitinib by combining with MET to regulate PI3K/AKT pathway in lung adenocarcinoma
por: Gao, Fangyan, et al.
Publicado: (2021)

Correlation of PD-L1 and SOCS3 Co-expression with the Prognosis of Hepatocellular Carcinoma Patients
por: Chen, Liuxi, et al.
Publicado: (2020)

Elemene treatment for NSCLC with multiple CNS metastases: a case report and literature review
por: Han, Yushan, et al.
Publicado: (2018)

β-elemene enhances the antitumor activity of erlotinib by inducing apoptosis through AMPK and MAPK pathways in TKI-resistant H1975 lung cancer cells
por: Wang, Jue, et al.
Publicado: (2021)

Inhibition of DNA-PK by gefitinib causes synergism between gefitinib and cisplatin in NSCLC
por: Pan, Chi, et al.
Publicado: (2020)

Roles of the m6A methyltransferases METTL3, METTL14, and WTAP in pulmonary tuberculosis
por: Zhang, Tian-Ping, et al.
Publicado: (2022)

RNA methyltransferase METTL16: Targets and function
por: Satterwhite, Emily R., et al.
Publicado: (2021)

m6A methyltransferase METTL3-induced lncRNA SNHG17 promotes lung adenocarcinoma gefitinib resistance by epigenetically repressing LATS2 expression
por: Zhang, Heng, et al.
Publicado: (2022)

Combined treatment with N‐acetylcysteine and gefitinib overcomes drug resistance to gefitinib in NSCLC cell line
por: Li, Jun, et al.
Publicado: (2019)

Solution structure of the RNA recognition domain of METTL3-METTL14 N(6)-methyladenosine methyltransferase
por: Huang, Jinbo, et al.
Publicado: (2018)

Pilot study of radiofrequency hyperthermia in combination with gefitinib in gefitinib‐effective patients with advanced NSCLC
por: Qin, Yijia, et al.
Publicado: (2016)

The role of RNA methyltransferase METTL3 in gynecologic cancers: Results and mechanisms
por: Zhang, Yuxiang, et al.
Publicado: (2023)

Structural insights into the RNA methyltransferase domain of METTL16
por: Ruszkowska, Agnieszka, et al.
Publicado: (2018)

The RNA Methyltransferase Complex of WTAP, METTL3, and METTL14 Regulates Mitotic Clonal Expansion in Adipogenesis
por: Kobayashi, Masatoshi, et al.
Publicado: (2018)

Elémens de Chimie
Publicado: (1836)

The inflammatory microenvironment and the urinary microbiome in the initiation and progression of bladder cancer
por: Huang, Xingxing, et al.
Publicado: (2020)

Baicalin Induces Apoptosis and Suppresses the Cell Cycle Progression of Lung Cancer Cells Through Downregulating Akt/mTOR Signaling Pathway
por: Sui, Xinbing, et al.
Publicado: (2021)

Combination of lysine‐specific demethylase 6A (KDM6A) and mismatch repair (MMR) status is a potential prognostic factor in colorectal cancer
por: Chen, Xiaying, et al.
Publicado: (2020)

The methyltransferase METTL3 negatively regulates nonalcoholic steatohepatitis (NASH) progression
por: Li, Xinzhi, et al.
Publicado: (2021)

Effect of Gefitinib Combined with Chemotherapy in Patients with Advanced NSCLC: A Retrospective Cohort Study
por: Dai, Lili, et al.
Publicado: (2022)

Emerging role of RNA methyltransferase METTL3 in gastrointestinal cancer
por: Wang, Qiang, et al.
Publicado: (2020)

The Role of RNA Methyltransferase METTL3 in Normal and Malignant Hematopoiesis
por: Wu, Xia, et al.
Publicado: (2022)

ABCC10 Plays a Significant Role in the Transport of Gefitinib and Contributes to Acquired Resistance to Gefitinib in NSCLC
por: Zhao, Hongbo, et al.
Publicado: (2018)

Antitumor effects of β-elemene via targeting the phosphorylation of insulin receptor
por: Wu, Dawei, et al.
Publicado: (2018)

Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1
por: Kong, Na, et al.
Publicado: (2021)

Élemens de pathologie chirurgicale

Human MettL3-MettL14 RNA adenine methyltransferase complex is active on double-stranded DNA containing lesions
por: Yu, Dan, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_2faau63jo59pqgnb4f75rcdmcp