Cargando…

Identification of critical genetic variants associated with metabolic phenotypes of the Japanese population

We performed a metabolome genome-wide association study for the Japanese population in the prospective cohort study of Tohoku Medical Megabank. By combining whole-genome sequencing and nontarget metabolome analyses, we identified a large number of novel associations between genetic variants and plas...

Descripción completa

Detalles Bibliográficos
Autores principales:	Koshiba, Seizo, Motoike, Ikuko N., Saigusa, Daisuke, Inoue, Jin, Aoki, Yuichi, Tadaka, Shu, Shirota, Matsuyuki, Katsuoka, Fumiki, Tamiya, Gen, Minegishi, Naoko, Fuse, Nobuo, Kinoshita, Kengo, Yamamoto, Masayuki
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659008/ https://www.ncbi.nlm.nih.gov/pubmed/33177615 http://dx.doi.org/10.1038/s42003-020-01383-5

Ejemplares similares

jMorp: Japanese Multi Omics Reference Panel
por: Tadaka, Shu, et al.
Publicado: (2018)

jMorp updates in 2020: large enhancement of multi-omics data resources on the general Japanese population
por: Tadaka, Shu, et al.
Publicado: (2020)

3.5KJPNv2: an allele frequency panel of 3552 Japanese individuals including the X chromosome
por: Tadaka, Shu, et al.
Publicado: (2019)

A genotype imputation method for de-identified haplotype reference information by using recurrent neural network
por: Kojima, Kaname, et al.
Publicado: (2020)

Japonica Array NEO with increased genome-wide coverage and abundant disease risk SNPs
por: Sakurai-Yageta, Mika, et al.
Publicado: (2021)

The structural origin of metabolic quantitative diversity
por: Koshiba, Seizo, et al.
Publicado: (2016)

Improved metabolomic data-based prediction of depressive symptoms using nonlinear machine learning with feature selection
por: Takahashi, Yuta, et al.
Publicado: (2020)

Impacts of NRF2 activation in non–small‐cell lung cancer cell lines on extracellular metabolites
por: Saigusa, Daisuke, et al.
Publicado: (2020)

Comparison of Kit-Based Metabolomics with Other Methodologies in a Large Cohort, towards Establishing Reference Values
por: Saigusa, Daisuke, et al.
Publicado: (2021)

Genetic loci for lung function in Japanese adults with adjustment for exhaled nitric oxide levels as airway inflammation indicator
por: Yamada, Mitsuhiro, et al.
Publicado: (2021)

Regional genetic differences among Japanese populations and performance of genotype imputation using whole-genome reference panel of the Tohoku Medical Megabank Project
por: Yasuda, Jun, et al.
Publicado: (2018)

Wide-Targeted Metabolome Analysis Identifies Potential Biomarkers for Prognosis Prediction of Epithelial Ovarian Cancer
por: Hishinuma, Eiji, et al.
Publicado: (2021)

Construction of a trio-based structural variation panel utilizing activated T lymphocytes and long-read sequencing technology
por: Otsuki, Akihito, et al.
Publicado: (2022)

ATTED-II in 2014: Evaluation of Gene Coexpression in Agriculturally Important Plants
por: Obayashi, Takeshi, et al.
Publicado: (2014)

Establishment of Protocols for Global Metabolomics by LC-MS for Biomarker Discovery
por: Saigusa, Daisuke, et al.
Publicado: (2016)

Identification of predictive biomarkers for endometrial cancer diagnosis and treatment response monitoring using plasma metabolome profiling
por: Hishinuma, Eiji, et al.
Publicado: (2023)

Validation of multiple single nucleotide variation calls by additional exome analysis with a semiconductor sequencer to supplement data of whole-genome sequencing of a human population
por: Motoike, Ikuko N, et al.
Publicado: (2014)

Establishment of Integrated Biobank for Precision Medicine and Personalized Healthcare: The Tohoku Medical Megabank Project
por: Fuse, Nobuo, et al.
Publicado: (2019)

Maternity Log study: a longitudinal lifelog monitoring and multiomics analysis for the early prediction of complicated pregnancy
por: Sugawara, Junichi, et al.
Publicado: (2019)

Plasma metabolic disturbances during pregnancy and postpartum in women with depression
por: Yu, Zhiqian, et al.
Publicado: (2022)

Novel candidates of pathogenic variants of the BRCA1 and BRCA2 genes from a dataset of 3,552 Japanese whole genomes (3.5KJPNv2)
por: Tokunaga, Hideki, et al.
Publicado: (2021)

Estimation of the carrier frequencies and proportions of potential patients by detecting causative gene variants associated with autosomal recessive bone dysplasia using a whole-genome reference panel of Japanese individuals
por: Nagaoka, Shinichi, et al.
Publicado: (2021)

Construction and integration of three de novo Japanese human genome assemblies toward a population-specific reference
por: Takayama, Jun, et al.
Publicado: (2021)

Discrepancies between human DNA, mRNA and protein reference sequences and their relation to single nucleotide variants in the human population
por: Shirota, Matsuyuki, et al.
Publicado: (2016)

Current status and future perspectives of the evaluation of missense variants by using three-dimensional structures of proteins
por: Shirota, Matsuyuki, et al.
Publicado: (2022)

Pathological variants in genes associated with disorders of sex development and central causes of hypogonadism in a whole-genome reference panel of 8380 Japanese individuals
por: Shiga, Naomi, et al.
Publicado: (2022)

Construction of JRG (Japanese reference genome) with single-molecule real-time sequencing
por: Nagasaki, Masao, et al.
Publicado: (2019)

COXPRESdb: a database of comparative gene coexpression networks of eleven species for mammals
por: Obayashi, Takeshi, et al.
Publicado: (2013)

dbTMM: an integrated database of large-scale cohort, genome and clinical data for the Tohoku Medical Megabank Project
por: Ogishima, Soichi, et al.
Publicado: (2021)

Construction of full-length Japanese reference panel of class I HLA genes with single-molecule, real-time sequencing
por: Mimori, Takahiro, et al.
Publicado: (2018)

Selective Elimination of NRF2-Activated Cells by Competition With Neighboring Cells in the Esophageal Epithelium
por: Hirose, Wataru, et al.
Publicado: (2022)

Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
por: Okazaki, Keito, et al.
Publicado: (2020)

Publisher Correction: Enhancer remodeling promotes tumor-initiating activity in NRF2-activated non-small cell lung cancers
por: Okazaki, Keito, et al.
Publicado: (2021)

Ion Concentration-Dependent Ion Conduction Mechanism of a Voltage-Sensitive Potassium Channel
por: Kasahara, Kota, et al.
Publicado: (2013)

Ion Concentration- and Voltage-Dependent Push and Pull Mechanisms of Potassium Channel Ion Conduction
por: Kasahara, Kota, et al.
Publicado: (2016)

Metabolomic changes in the mouse retina after optic nerve injury
por: Sato, Kota, et al.
Publicado: (2018)

Rare variant discovery by deep whole-genome sequencing of 1,070 Japanese individuals
por: Nagasaki, Masao, et al.
Publicado: (2015)

Genome-wide Association Study of Axial Length in Population-based Cohorts in Japan: The Tohoku Medical Megabank Organization Eye Study
por: Fuse, Nobuo, et al.
Publicado: (2022)

Machine learning approaches to predict gestational age in normal and complicated pregnancies via urinary metabolomics analysis
por: Yamauchi, Takafumi, et al.
Publicado: (2021)

ATTED-II in 2016: A Plant Coexpression Database Towards Lineage-Specific Coexpression
por: Aoki, Yuichi, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_bua35g52am7f8o4g496ishlgnn