Cargando…
Phytosterol supplementation in the treatment of dyslipidemia in children and adolescents: a systematic review
OBJECTIVE: To carry out a systematic review on the effects of phytosterol supplementation on the treatment of dyslipidemia in children and adolescents. DATA SOURCES: Review in the SciELO, Lilacs, Bireme, PubMed and Web of Science databases, with no time limit. Descriptors: phytosterols or plant ster...
Autores principales: | , |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Sociedade de Pediatria de São Paulo
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659030/ https://www.ncbi.nlm.nih.gov/pubmed/33206867 http://dx.doi.org/10.1590/1984-0462/2021/39/2019389 |
_version_ | 1783608774368428032 |
---|---|
author | Mantovani, Luisa Montone Pugliese, Camila |
author_facet | Mantovani, Luisa Montone Pugliese, Camila |
author_sort | Mantovani, Luisa Montone |
collection | PubMed |
description | OBJECTIVE: To carry out a systematic review on the effects of phytosterol supplementation on the treatment of dyslipidemia in children and adolescents. DATA SOURCES: Review in the SciELO, Lilacs, Bireme, PubMed and Web of Science databases, with no time limit. Descriptors: phytosterols or plant sterols and dyslipidemias, hypercholesterolemia, cholesterol, children, adolescent, in English and Portuguese. The articles included were published in Portuguese, English or Spanish and evaluated the effect of phytosterol supplementation in pediatric patients with dyslipidemia. Documents that involved adults or animals, review papers, case studies and abstracts were excluded. Two authors performed independent extraction of articles. Of 113 abstracts, 19 were read in full and 12 were used in this manuscript. DATA SYNTHESIS: Phytosterol supplementation to reduce cholesterol levels has been shown to be effective in reducing LDL-cholesterol levels by approximately 10%, with reductions above 10% in LDL-cholesterol levels observed after 8 to 12 weeks of intervention. Studies have not shown significant changes in HDL-cholesterol and triglyceride levels. Based on the absence of adverse effects, its use seems to be safe and of good tolerance in children and adolescents. CONCLUSIONS: Phytosterol supplementation seems to be of great therapeutic aid for the treatment of hypercholesterolemia in children and adolescents. Further studies assessing the long-term effect of phytosterol supplementation are necessary. |
format | Online Article Text |
id | pubmed-7659030 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Sociedade de Pediatria de São Paulo |
record_format | MEDLINE/PubMed |
spelling | pubmed-76590302020-11-20 Phytosterol supplementation in the treatment of dyslipidemia in children and adolescents: a systematic review Mantovani, Luisa Montone Pugliese, Camila Rev Paul Pediatr Review Article OBJECTIVE: To carry out a systematic review on the effects of phytosterol supplementation on the treatment of dyslipidemia in children and adolescents. DATA SOURCES: Review in the SciELO, Lilacs, Bireme, PubMed and Web of Science databases, with no time limit. Descriptors: phytosterols or plant sterols and dyslipidemias, hypercholesterolemia, cholesterol, children, adolescent, in English and Portuguese. The articles included were published in Portuguese, English or Spanish and evaluated the effect of phytosterol supplementation in pediatric patients with dyslipidemia. Documents that involved adults or animals, review papers, case studies and abstracts were excluded. Two authors performed independent extraction of articles. Of 113 abstracts, 19 were read in full and 12 were used in this manuscript. DATA SYNTHESIS: Phytosterol supplementation to reduce cholesterol levels has been shown to be effective in reducing LDL-cholesterol levels by approximately 10%, with reductions above 10% in LDL-cholesterol levels observed after 8 to 12 weeks of intervention. Studies have not shown significant changes in HDL-cholesterol and triglyceride levels. Based on the absence of adverse effects, its use seems to be safe and of good tolerance in children and adolescents. CONCLUSIONS: Phytosterol supplementation seems to be of great therapeutic aid for the treatment of hypercholesterolemia in children and adolescents. Further studies assessing the long-term effect of phytosterol supplementation are necessary. Sociedade de Pediatria de São Paulo 2020-11-11 /pmc/articles/PMC7659030/ /pubmed/33206867 http://dx.doi.org/10.1590/1984-0462/2021/39/2019389 Text en https://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License |
spellingShingle | Review Article Mantovani, Luisa Montone Pugliese, Camila Phytosterol supplementation in the treatment of dyslipidemia in children and adolescents: a systematic review |
title | Phytosterol supplementation in the treatment of dyslipidemia in
children and adolescents: a systematic review |
title_full | Phytosterol supplementation in the treatment of dyslipidemia in
children and adolescents: a systematic review |
title_fullStr | Phytosterol supplementation in the treatment of dyslipidemia in
children and adolescents: a systematic review |
title_full_unstemmed | Phytosterol supplementation in the treatment of dyslipidemia in
children and adolescents: a systematic review |
title_short | Phytosterol supplementation in the treatment of dyslipidemia in
children and adolescents: a systematic review |
title_sort | phytosterol supplementation in the treatment of dyslipidemia in
children and adolescents: a systematic review |
topic | Review Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659030/ https://www.ncbi.nlm.nih.gov/pubmed/33206867 http://dx.doi.org/10.1590/1984-0462/2021/39/2019389 |
work_keys_str_mv | AT mantovaniluisamontone phytosterolsupplementationinthetreatmentofdyslipidemiainchildrenandadolescentsasystematicreview AT pugliesecamila phytosterolsupplementationinthetreatmentofdyslipidemiainchildrenandadolescentsasystematicreview |