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Recurrent SETD2 mutation in NPM1-mutated acute myeloid leukemia
SETD2 is the only methyltransferase for H3K36me3, and our previous study has firstly demonstrated that it functioned as one tumor suppressor in hematopoiesis. Consistent with it, SETD2 mutation, which led to its loss of function, was identified in AML. However, the distribution and function of SETD2...
| Autores principales: | , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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BioMed Central
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659109/ https://www.ncbi.nlm.nih.gov/pubmed/33292784 http://dx.doi.org/10.1186/s40364-020-00243-y |