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The Roles of CCN1/CYR61 in Pulmonary Diseases
CCN1 (cysteine-rich 61, connective tissue growth factor, and nephroblastoma-1), previously named CYR61 (cysteine-rich angiogenic inducer 61) belongs to the CCN family of matricellular proteins. CCN1 plays critical roles in the regulation of proliferation, differentiation, apoptosis, angiogenesis, an...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
MDPI
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659478/ https://www.ncbi.nlm.nih.gov/pubmed/33105556 http://dx.doi.org/10.3390/ijms21217810 |
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author | Zhu, Yin Almuntashiri, Sultan Han, Yohan Wang, Xiaoyun R. Somanath, Payaningal Zhang, Duo |
author_facet | Zhu, Yin Almuntashiri, Sultan Han, Yohan Wang, Xiaoyun R. Somanath, Payaningal Zhang, Duo |
author_sort | Zhu, Yin |
collection | PubMed |
description | CCN1 (cysteine-rich 61, connective tissue growth factor, and nephroblastoma-1), previously named CYR61 (cysteine-rich angiogenic inducer 61) belongs to the CCN family of matricellular proteins. CCN1 plays critical roles in the regulation of proliferation, differentiation, apoptosis, angiogenesis, and fibrosis. Recent studies have extensively characterized the important physiological and pathological roles of CCN1 in various tissues and organs. In this review, we summarize both basic and clinical aspects of CCN1 in pulmonary diseases, including acute lung injury (ALI), chronic obstructive pulmonary disease (COPD), lung fibrosis, pulmonary arterial hypertension (PAH), lung infection, and lung cancer. We also emphasize the important challenges for future investigations to better understand the CCN1 and its role in physiology and pathology, as well as the questions that need to be addressed for the therapeutic development of CCN1 antagonists in various lung diseases. |
format | Online Article Text |
id | pubmed-7659478 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | MDPI |
record_format | MEDLINE/PubMed |
spelling | pubmed-76594782020-11-13 The Roles of CCN1/CYR61 in Pulmonary Diseases Zhu, Yin Almuntashiri, Sultan Han, Yohan Wang, Xiaoyun R. Somanath, Payaningal Zhang, Duo Int J Mol Sci Review CCN1 (cysteine-rich 61, connective tissue growth factor, and nephroblastoma-1), previously named CYR61 (cysteine-rich angiogenic inducer 61) belongs to the CCN family of matricellular proteins. CCN1 plays critical roles in the regulation of proliferation, differentiation, apoptosis, angiogenesis, and fibrosis. Recent studies have extensively characterized the important physiological and pathological roles of CCN1 in various tissues and organs. In this review, we summarize both basic and clinical aspects of CCN1 in pulmonary diseases, including acute lung injury (ALI), chronic obstructive pulmonary disease (COPD), lung fibrosis, pulmonary arterial hypertension (PAH), lung infection, and lung cancer. We also emphasize the important challenges for future investigations to better understand the CCN1 and its role in physiology and pathology, as well as the questions that need to be addressed for the therapeutic development of CCN1 antagonists in various lung diseases. MDPI 2020-10-22 /pmc/articles/PMC7659478/ /pubmed/33105556 http://dx.doi.org/10.3390/ijms21217810 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/). |
spellingShingle | Review Zhu, Yin Almuntashiri, Sultan Han, Yohan Wang, Xiaoyun R. Somanath, Payaningal Zhang, Duo The Roles of CCN1/CYR61 in Pulmonary Diseases |
title | The Roles of CCN1/CYR61 in Pulmonary Diseases |
title_full | The Roles of CCN1/CYR61 in Pulmonary Diseases |
title_fullStr | The Roles of CCN1/CYR61 in Pulmonary Diseases |
title_full_unstemmed | The Roles of CCN1/CYR61 in Pulmonary Diseases |
title_short | The Roles of CCN1/CYR61 in Pulmonary Diseases |
title_sort | roles of ccn1/cyr61 in pulmonary diseases |
topic | Review |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659478/ https://www.ncbi.nlm.nih.gov/pubmed/33105556 http://dx.doi.org/10.3390/ijms21217810 |
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