Human T Cells Expressing a CD19 CAR-T Receptor Provide Insights into Mechanisms of Human CD19-Positive β Cell Destruction

Autoimmune destruction of pancreatic β cells underlies type 1 diabetes (T1D). To understand T cell-mediated immune effects on human pancreatic β cells, we combine β cell-specific expression of a model antigen, CD19, and anti-CD19 chimeric antigen receptor T (CAR-T) cells. Coculturing CD19-expressing...

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Detalles Bibliográficos
Autores principales: Ma, Haiting, Jeppesen, Jacob F., Jaenisch, Rudolf
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659530/
https://www.ncbi.nlm.nih.gov/pubmed/33205073
http://dx.doi.org/10.1016/j.xcrm.2020.100097

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659530/
https://www.ncbi.nlm.nih.gov/pubmed/33205073
http://dx.doi.org/10.1016/j.xcrm.2020.100097

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