Malignant Transformation Involving CXXC4 Mutations Identified in a Leukemic Progression Model of Severe Congenital Neutropenia

Severe congenital neutropenia (SCN) patients treated with CSF3/G-CSF to alleviate neutropenia frequently develop acute myeloid leukemia (AML). A common pattern of leukemic transformation involves the appearance of hematopoietic clones with CSF3 receptor (CSF3R) mutations in the neutropenic phase, fo...

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Detalles Bibliográficos
Autores principales: Olofsen, Patricia A., Fatrai, Szabolcs, van Strien, Paulina M.H., Obenauer, Julia C., de Looper, Hans W.J., Hoogenboezem, Remco M., Erpelinck-Verschueren, Claudia A.J., Vermeulen, Michael P.W.M., Roovers, Onno, Haferlach, Torsten, Jansen, Joop H., Ghazvini, Mehrnaz, Bindels, Eric M.J., Schneider, Rebekka K., de Pater, Emma M., Touw, Ivo P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659587/
https://www.ncbi.nlm.nih.gov/pubmed/33205068
http://dx.doi.org/10.1016/j.xcrm.2020.100074

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