Notch2 complements Notch1 to mediate inductive signaling that initiates early T cell development

Notch signaling is the dominant intercellular signaling input during the earliest stages of T cell development in the thymus. Although Notch1 is known to be indispensable, we show that it does not mediate all Notch signaling in precommitment stages: Notch2 initially works in parallel to promote earl...

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Detalles Bibliográficos
Autores principales: Romero-Wolf, Maile, Shin, Boyoung, Zhou, Wen, Koizumi, Maria, Rothenberg, Ellen V., Hosokawa, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Rockefeller University Press 2020
Materias:
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Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7659720/
https://www.ncbi.nlm.nih.gov/pubmed/32756905
http://dx.doi.org/10.1083/jcb.202005093

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