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Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits
OBJECTIVES: The objective is to evaluate the pattern of cognitive deficits after electroconvulsive therapy (ECT); to ascertain the role of various psychosocial, illness and treatment-related parameters on cognitive functions after ECT; and to evaluate the effect of donepezil on various cognitive def...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Wolters Kluwer - Medknow
2019
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660005/ https://www.ncbi.nlm.nih.gov/pubmed/33223724 http://dx.doi.org/10.4103/ipj.ipj_105_20 |
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author | Prakash, Jyoti Chaudhury, Suprakash Chatterjee, Kaushik Kotwal, A. Srivastava, Kalpana Saha, Amitav |
author_facet | Prakash, Jyoti Chaudhury, Suprakash Chatterjee, Kaushik Kotwal, A. Srivastava, Kalpana Saha, Amitav |
author_sort | Prakash, Jyoti |
collection | PubMed |
description | OBJECTIVES: The objective is to evaluate the pattern of cognitive deficits after electroconvulsive therapy (ECT); to ascertain the role of various psychosocial, illness and treatment-related parameters on cognitive functions after ECT; and to evaluate the effect of donepezil on various cognitive deficits. MATERIALS AND METHODS: A triple-blind randomized controlled trial was undertaken. Ninety patients undergoing ECT were included into study after due consent and institutional ethical approval. They were randomized into two groups: one using donepezil with ECT and the other using placebo with ECT. Various cognitive parameters were studied before ECT, after a course of ECT and after 4 weeks of last ECT. Findings were assessed in the light of available socialdemographic and clinical parameters and existing literature. RESULTS: ECT was found to be an effective therapeutic modality. Immediate memory worsened over the course of ECT till after 4 weeks of ECT. Augmentation of donepezil was found useful. It sped up the improvement of general memory and working memory during ECT. CONCLUSION: Donepezil has therapeutic and prophylactic benefit on cognition of patients undergoing ECT over the course of treatment till 4 weeks after the ECT. |
format | Online Article Text |
id | pubmed-7660005 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2019 |
publisher | Wolters Kluwer - Medknow |
record_format | MEDLINE/PubMed |
spelling | pubmed-76600052020-11-19 Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits Prakash, Jyoti Chaudhury, Suprakash Chatterjee, Kaushik Kotwal, A. Srivastava, Kalpana Saha, Amitav Ind Psychiatry J Original Article OBJECTIVES: The objective is to evaluate the pattern of cognitive deficits after electroconvulsive therapy (ECT); to ascertain the role of various psychosocial, illness and treatment-related parameters on cognitive functions after ECT; and to evaluate the effect of donepezil on various cognitive deficits. MATERIALS AND METHODS: A triple-blind randomized controlled trial was undertaken. Ninety patients undergoing ECT were included into study after due consent and institutional ethical approval. They were randomized into two groups: one using donepezil with ECT and the other using placebo with ECT. Various cognitive parameters were studied before ECT, after a course of ECT and after 4 weeks of last ECT. Findings were assessed in the light of available socialdemographic and clinical parameters and existing literature. RESULTS: ECT was found to be an effective therapeutic modality. Immediate memory worsened over the course of ECT till after 4 weeks of ECT. Augmentation of donepezil was found useful. It sped up the improvement of general memory and working memory during ECT. CONCLUSION: Donepezil has therapeutic and prophylactic benefit on cognition of patients undergoing ECT over the course of treatment till 4 weeks after the ECT. Wolters Kluwer - Medknow 2019 2020-08-14 /pmc/articles/PMC7660005/ /pubmed/33223724 http://dx.doi.org/10.4103/ipj.ipj_105_20 Text en Copyright: © 2020 Industrial Psychiatry Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms. |
spellingShingle | Original Article Prakash, Jyoti Chaudhury, Suprakash Chatterjee, Kaushik Kotwal, A. Srivastava, Kalpana Saha, Amitav Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits |
title | Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits |
title_full | Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits |
title_fullStr | Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits |
title_full_unstemmed | Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits |
title_short | Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits |
title_sort | therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits |
topic | Original Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660005/ https://www.ncbi.nlm.nih.gov/pubmed/33223724 http://dx.doi.org/10.4103/ipj.ipj_105_20 |
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