Cargando…

Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits

OBJECTIVES: The objective is to evaluate the pattern of cognitive deficits after electroconvulsive therapy (ECT); to ascertain the role of various psychosocial, illness and treatment-related parameters on cognitive functions after ECT; and to evaluate the effect of donepezil on various cognitive def...

Descripción completa

Detalles Bibliográficos
Autores principales: Prakash, Jyoti, Chaudhury, Suprakash, Chatterjee, Kaushik, Kotwal, A., Srivastava, Kalpana, Saha, Amitav
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Wolters Kluwer - Medknow 2019
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660005/
https://www.ncbi.nlm.nih.gov/pubmed/33223724
http://dx.doi.org/10.4103/ipj.ipj_105_20
_version_ 1783608916079280128
author Prakash, Jyoti
Chaudhury, Suprakash
Chatterjee, Kaushik
Kotwal, A.
Srivastava, Kalpana
Saha, Amitav
author_facet Prakash, Jyoti
Chaudhury, Suprakash
Chatterjee, Kaushik
Kotwal, A.
Srivastava, Kalpana
Saha, Amitav
author_sort Prakash, Jyoti
collection PubMed
description OBJECTIVES: The objective is to evaluate the pattern of cognitive deficits after electroconvulsive therapy (ECT); to ascertain the role of various psychosocial, illness and treatment-related parameters on cognitive functions after ECT; and to evaluate the effect of donepezil on various cognitive deficits. MATERIALS AND METHODS: A triple-blind randomized controlled trial was undertaken. Ninety patients undergoing ECT were included into study after due consent and institutional ethical approval. They were randomized into two groups: one using donepezil with ECT and the other using placebo with ECT. Various cognitive parameters were studied before ECT, after a course of ECT and after 4 weeks of last ECT. Findings were assessed in the light of available socialdemographic and clinical parameters and existing literature. RESULTS: ECT was found to be an effective therapeutic modality. Immediate memory worsened over the course of ECT till after 4 weeks of ECT. Augmentation of donepezil was found useful. It sped up the improvement of general memory and working memory during ECT. CONCLUSION: Donepezil has therapeutic and prophylactic benefit on cognition of patients undergoing ECT over the course of treatment till 4 weeks after the ECT.
format Online
Article
Text
id pubmed-7660005
institution National Center for Biotechnology Information
language English
publishDate 2019
publisher Wolters Kluwer - Medknow
record_format MEDLINE/PubMed
spelling pubmed-76600052020-11-19 Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits Prakash, Jyoti Chaudhury, Suprakash Chatterjee, Kaushik Kotwal, A. Srivastava, Kalpana Saha, Amitav Ind Psychiatry J Original Article OBJECTIVES: The objective is to evaluate the pattern of cognitive deficits after electroconvulsive therapy (ECT); to ascertain the role of various psychosocial, illness and treatment-related parameters on cognitive functions after ECT; and to evaluate the effect of donepezil on various cognitive deficits. MATERIALS AND METHODS: A triple-blind randomized controlled trial was undertaken. Ninety patients undergoing ECT were included into study after due consent and institutional ethical approval. They were randomized into two groups: one using donepezil with ECT and the other using placebo with ECT. Various cognitive parameters were studied before ECT, after a course of ECT and after 4 weeks of last ECT. Findings were assessed in the light of available socialdemographic and clinical parameters and existing literature. RESULTS: ECT was found to be an effective therapeutic modality. Immediate memory worsened over the course of ECT till after 4 weeks of ECT. Augmentation of donepezil was found useful. It sped up the improvement of general memory and working memory during ECT. CONCLUSION: Donepezil has therapeutic and prophylactic benefit on cognition of patients undergoing ECT over the course of treatment till 4 weeks after the ECT. Wolters Kluwer - Medknow 2019 2020-08-14 /pmc/articles/PMC7660005/ /pubmed/33223724 http://dx.doi.org/10.4103/ipj.ipj_105_20 Text en Copyright: © 2020 Industrial Psychiatry Journal http://creativecommons.org/licenses/by-nc-sa/4.0 This is an open access journal, and articles are distributed under the terms of the Creative Commons Attribution-NonCommercial-ShareAlike 4.0 License, which allows others to remix, tweak, and build upon the work non-commercially, as long as appropriate credit is given and the new creations are licensed under the identical terms.
spellingShingle Original Article
Prakash, Jyoti
Chaudhury, Suprakash
Chatterjee, Kaushik
Kotwal, A.
Srivastava, Kalpana
Saha, Amitav
Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits
title Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits
title_full Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits
title_fullStr Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits
title_full_unstemmed Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits
title_short Therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits
title_sort therapeutic and prophylactic role of cognitive enhancers in electroconvulsive therapy-induced cognitive deficits
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660005/
https://www.ncbi.nlm.nih.gov/pubmed/33223724
http://dx.doi.org/10.4103/ipj.ipj_105_20
work_keys_str_mv AT prakashjyoti therapeuticandprophylacticroleofcognitiveenhancersinelectroconvulsivetherapyinducedcognitivedeficits
AT chaudhurysuprakash therapeuticandprophylacticroleofcognitiveenhancersinelectroconvulsivetherapyinducedcognitivedeficits
AT chatterjeekaushik therapeuticandprophylacticroleofcognitiveenhancersinelectroconvulsivetherapyinducedcognitivedeficits
AT kotwala therapeuticandprophylacticroleofcognitiveenhancersinelectroconvulsivetherapyinducedcognitivedeficits
AT srivastavakalpana therapeuticandprophylacticroleofcognitiveenhancersinelectroconvulsivetherapyinducedcognitivedeficits
AT sahaamitav therapeuticandprophylacticroleofcognitiveenhancersinelectroconvulsivetherapyinducedcognitivedeficits