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Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke

Recovery of skilled movement after stroke is assumed to depend on motor learning. However, the capacity for motor learning and factors that influence motor learning after stroke have received little attention. In this study, we first compared motor skill acquisition and retention between well-recove...

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Autores principales: Espenhahn, Svenja, Rossiter, Holly E, van Wijk, Bernadette C M, Redman, Nell, Rondina, Jane M, Diedrichsen, Joern, Ward, Nick S
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660041/
https://www.ncbi.nlm.nih.gov/pubmed/33215085
http://dx.doi.org/10.1093/braincomms/fcaa161
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author Espenhahn, Svenja
Rossiter, Holly E
van Wijk, Bernadette C M
Redman, Nell
Rondina, Jane M
Diedrichsen, Joern
Ward, Nick S
author_facet Espenhahn, Svenja
Rossiter, Holly E
van Wijk, Bernadette C M
Redman, Nell
Rondina, Jane M
Diedrichsen, Joern
Ward, Nick S
author_sort Espenhahn, Svenja
collection PubMed
description Recovery of skilled movement after stroke is assumed to depend on motor learning. However, the capacity for motor learning and factors that influence motor learning after stroke have received little attention. In this study, we first compared motor skill acquisition and retention between well-recovered stroke patients and age- and performance-matched healthy controls. We then tested whether beta oscillations (15–30 Hz) from sensorimotor cortices contribute to predicting training-related motor performance. Eighteen well-recovered chronic stroke survivors (mean age 64 ± 8 years, range: 50–74 years) and 20 age- and sex-matched healthy controls were trained on a continuous tracking task and subsequently retested after initial training (45–60 min and 24 h later). Scalp electroencephalography was recorded during the performance of a simple motor task before each training and retest session. Stroke patients demonstrated capacity for motor skill learning, but it was diminished compared to age- and performance-matched healthy controls. Furthermore, although the properties of beta oscillations prior to training were comparable between stroke patients and healthy controls, stroke patients did show less change in beta measures with motor learning. Lastly, although beta oscillations did not help to predict motor performance immediately after training, contralateral (ipsilesional) sensorimotor cortex post-movement beta rebound measured after training helped predict future motor performance, 24 h after training. This finding suggests that neurophysiological measures such as beta oscillations can help predict response to motor training in chronic stroke patients and may offer novel targets for therapeutic interventions.
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spelling pubmed-76600412020-11-18 Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke Espenhahn, Svenja Rossiter, Holly E van Wijk, Bernadette C M Redman, Nell Rondina, Jane M Diedrichsen, Joern Ward, Nick S Brain Commun Original Article Recovery of skilled movement after stroke is assumed to depend on motor learning. However, the capacity for motor learning and factors that influence motor learning after stroke have received little attention. In this study, we first compared motor skill acquisition and retention between well-recovered stroke patients and age- and performance-matched healthy controls. We then tested whether beta oscillations (15–30 Hz) from sensorimotor cortices contribute to predicting training-related motor performance. Eighteen well-recovered chronic stroke survivors (mean age 64 ± 8 years, range: 50–74 years) and 20 age- and sex-matched healthy controls were trained on a continuous tracking task and subsequently retested after initial training (45–60 min and 24 h later). Scalp electroencephalography was recorded during the performance of a simple motor task before each training and retest session. Stroke patients demonstrated capacity for motor skill learning, but it was diminished compared to age- and performance-matched healthy controls. Furthermore, although the properties of beta oscillations prior to training were comparable between stroke patients and healthy controls, stroke patients did show less change in beta measures with motor learning. Lastly, although beta oscillations did not help to predict motor performance immediately after training, contralateral (ipsilesional) sensorimotor cortex post-movement beta rebound measured after training helped predict future motor performance, 24 h after training. This finding suggests that neurophysiological measures such as beta oscillations can help predict response to motor training in chronic stroke patients and may offer novel targets for therapeutic interventions. Oxford University Press 2020-10-07 /pmc/articles/PMC7660041/ /pubmed/33215085 http://dx.doi.org/10.1093/braincomms/fcaa161 Text en © The Author(s) (2020). Published by Oxford University Press on behalf of the Guarantors of Brain. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Espenhahn, Svenja
Rossiter, Holly E
van Wijk, Bernadette C M
Redman, Nell
Rondina, Jane M
Diedrichsen, Joern
Ward, Nick S
Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke
title Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke
title_full Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke
title_fullStr Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke
title_full_unstemmed Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke
title_short Sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke
title_sort sensorimotor cortex beta oscillations reflect motor skill learning ability after stroke
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660041/
https://www.ncbi.nlm.nih.gov/pubmed/33215085
http://dx.doi.org/10.1093/braincomms/fcaa161
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