Cargando…

Acute Systemic Inflammatory Response Alters Transcription Profile of Genes Related to Immune Response and Ca(2+) Homeostasis in Hippocampus; Relevance to Neurodegenerative Disorders

Acute systemic inflammatory response (SIR) triggers an alteration in the transcription of brain genes related to neuroinflammation, oxidative stress and cells death. These changes are also characteristic for Alzheimer’s disease (AD) neuropathology. Our aim was to evaluate gene expression patterns in...

Descripción completa

Detalles Bibliográficos
Autores principales:	Czapski, Grzegorz A., Zhao, Yuhai, Lukiw, Walter J., Strosznajder, Joanna B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660108/ https://www.ncbi.nlm.nih.gov/pubmed/33105802 http://dx.doi.org/10.3390/ijms21217838

Ejemplares similares

Alterations of Transcription of Genes Coding Anti-oxidative and Mitochondria-Related Proteins in Amyloid β Toxicity: Relevance to Alzheimer’s Disease
por: Cieślik, Magdalena, et al.
Publicado: (2019)

Down-regulation of cyclin D2 in amyloid β toxicity, inflammation, and Alzheimer’s disease
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

Glutamate and GABA in Microglia-Neuron Cross-Talk in Alzheimer’s Disease
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

The Lipoxygenases: Their Regulation and Implication in Alzheimer’s Disease
por: Czapski, Grzegorz A., et al.
Publicado: (2015)

The Molecular Mechanism of Amyloid β42 Peptide Toxicity: The Role of Sphingosine Kinase-1 and Mitochondrial Sirtuins
por: Cieślik, Magdalena, et al.
Publicado: (2015)

The Role of Ceramide and Sphingosine-1-Phosphate in Alzheimer’s Disease and Other Neurodegenerative Disorders
por: Czubowicz, Kinga, et al.
Publicado: (2019)

Fingolimod Affects Transcription of Genes Encoding Enzymes of Ceramide Metabolism in Animal Model of Alzheimer’s Disease
por: Jęśko, Henryk, et al.
Publicado: (2020)

Alpha-synuclein alters differently gene expression of Sirts, PARPs and other stress response proteins: implications for neurodegenerative disorders
por: Motyl, J., et al.
Publicado: (2017)

Inhibition of Poly(ADP-ribose) Polymerase-1 Enhances Gene Expression of Selected Sirtuins and APP Cleaving Enzymes in Amyloid Beta Cytotoxicity
por: Wencel, Przemysław L., et al.
Publicado: (2017)

Sirtuins and Their Roles in Brain Aging and Neurodegenerative Disorders
por: Jęśko, Henryk, et al.
Publicado: (2016)

Secretory Products of the Human GI Tract Microbiome and Their Potential Impact on Alzheimer's Disease (AD): Detection of Lipopolysaccharide (LPS) in AD Hippocampus
por: Zhao, Yuhai, et al.
Publicado: (2017)

SARS-CoV-2 Neuroinvasion, Inflammatory Neurodegeneration and Alzheimer's Disease
por: Zhao, Yuhai, et al.
Publicado: (2022)

Neurofilament Light (NF-L) Chain Protein from a Highly Polymerized Structural Component of the Neuronal Cytoskeleton to a Neurodegenerative Disease Biomarker in the Periphery
por: Zhao, Yuhai, et al.
Publicado: (2021)

The Novel Role of PPAR Alpha in the Brain: Promising Target in Therapy of Alzheimer’s Disease and Other Neurodegenerative Disorders
por: Wójtowicz, Sylwia, et al.
Publicado: (2020)

Gastrointestinal Tract Microbiome-Derived Pro-inflammatory Neurotoxins in Alzheimer’s Disease
por: Zhao, Yuhai, et al.
Publicado: (2021)

Lipopolysaccharide (LPS) Accumulates in Neocortical Neurons of Alzheimer’s Disease (AD) Brain and Impairs Transcription in Human Neuronal-Glial Primary Co-cultures
por: Zhao, Yuhai, et al.
Publicado: (2017)

Fission Impossible: Stabilized miRNA-Based Analogs in Neurodegenerative Disease
por: Lukiw, Walter J.
Publicado: (2022)

Up-Regulation of miRNA-146a in Progressive, Age-Related Inflammatory Neurodegenerative Disorders of the Human CNS
por: Alexandrov, Peter N., et al.
Publicado: (2014)

Age-Related Transcriptional Deregulation of Genes Coding Synaptic Proteins in Alzheimer's Disease Murine Model: Potential Neuroprotective Effect of Fingolimod
por: Jęśko, Henryk, et al.
Publicado: (2021)

The Cross-Talk Between Sphingolipids and Insulin-Like Growth Factor Signaling: Significance for Aging and Neurodegeneration
por: Jęśko, Henryk, et al.
Publicado: (2018)

Modulatory Effects of Fingolimod (FTY720) on the Expression of Sphingolipid Metabolism-Related Genes in an Animal Model of Alzheimer’s Disease
por: Jęśko, Henryk, et al.
Publicado: (2018)

Down-Regulation of Essential Synaptic Components by GI-Tract Microbiome-Derived Lipopolysaccharide (LPS) in LPS-Treated Human Neuronal-Glial (HNG) Cells in Primary Culture: Relevance to Alzheimer’s Disease (AD)
por: Zhao, Yuhai, et al.
Publicado: (2019)

Induction of the pro-inflammatory NF-kB-sensitive miRNA-146a by human neurotrophic viruses
por: Hill, James M., et al.
Publicado: (2015)

Citrin mediated metabolic rewiring in response to altered basal subcellular Ca(2+) homeostasis
por: Koshenov, Zhanat, et al.
Publicado: (2022)

Aversive stimulus-tuned responses in the CA1 of the dorsal hippocampus
por: Barth, Albert M., et al.
Publicado: (2023)

Microtubule Cytoskeletal Network Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders
por: Gąssowska-Dobrowolska, Magdalena, et al.
Publicado: (2023)

Gastrointestinal (GI)-Tract Microbiome Derived Neurotoxins and their Potential Contribution to Inflammatory Neurodegeneration in Alzheimer’s Disease (AD)
por: Lukiw, Walter J., et al.
Publicado: (2021)

Structural Plasticity of the Hippocampus in Neurodegenerative Diseases
por: Weerasinghe-Mudiyanselage, Poornima D. E., et al.
Publicado: (2022)

TREM2 signaling, miRNA-34a and the extinction of phagocytosis
por: Zhao, Yuhai, et al.
Publicado: (2013)

Microbiome-Mediated Upregulation of MicroRNA-146a in Sporadic Alzheimer’s Disease
por: Zhao, Yuhai, et al.
Publicado: (2018)

Untangling the brain's neuroinflammatory and neurodegenerative transcriptional responses
por: Srinivasan, Karpagam, et al.
Publicado: (2016)

Synaptic Alterations in a Transgenic Model of Tuberous Sclerosis Complex: Relevance to Autism Spectrum Disorders
por: Czapski, Grzegorz A., et al.
Publicado: (2021)

Prenatal stress causes alterations in the morphology of microglia and the inflammatory response of the hippocampus of adult female mice
por: Diz-Chaves, Yolanda, et al.
Publicado: (2012)

Generation of Reactive Oxygen Species (ROS) and Pro-Inflammatory Signaling in Human Brain Cells in Primary Culture
por: Lukiw, Walter J., et al.
Publicado: (2012)

Relevance of the Anti-Inflammatory Properties of Curcumin in Neurodegenerative Diseases and Depression
por: Tizabi, Yousef, et al.
Publicado: (2014)

Allergic Rhinitis in Rats Is Associated with an Inflammatory Response of the Hippocampus
por: Yang, Shasha, et al.
Publicado: (2018)

Zinc homeostasis and neurodegenerative disorders
por: Szewczyk, Bernadeta
Publicado: (2013)

Editorial: Neural immuno-inflammatory response in neurodegenerative diseases
por: Ge, Xintong
Publicado: (2023)

Deficits in the miRNA-34a-regulated endogenous TREM2 phagocytosis sensor-receptor in Alzheimer's disease (AD); an update
por: Bhattacharjee, Surjyadipta, et al.
Publicado: (2014)

Over-Expressed Pathogenic miRNAs in Alzheimer’s Disease (AD) and Prion Disease (PrD) Drive Deficits in TREM2-Mediated Aβ42 Peptide Clearance
por: Zhao, Yuhai, et al.
Publicado: (2016)

Cannot write session to /tmp/vufind_sessions/sess_aftcu7b7o9v7kc0c6gsufj1vv7