Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids

Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidac...

Descripción completa

Detalles Bibliográficos
Autores principales: Ka, Seydou, Koirala, Manoj, Mérindol, Natacha, Desgagné-Penix, Isabel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660210/
https://www.ncbi.nlm.nih.gov/pubmed/33113950
http://dx.doi.org/10.3390/molecules25214901
_version_ 1783608963635347456
author Ka, Seydou
Koirala, Manoj
Mérindol, Natacha
Desgagné-Penix, Isabel
author_facet Ka, Seydou
Koirala, Manoj
Mérindol, Natacha
Desgagné-Penix, Isabel
author_sort Ka, Seydou
collection PubMed
description Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer’s disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest.
format Online
Article
Text
id pubmed-7660210
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher MDPI
record_format MEDLINE/PubMed
spelling pubmed-76602102020-11-13 Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids Ka, Seydou Koirala, Manoj Mérindol, Natacha Desgagné-Penix, Isabel Molecules Review Alkaloids are an important group of specialized nitrogen metabolites with a wide range of biochemical and pharmacological effects. Since the first publication on lycorine in 1877, more than 650 alkaloids have been extracted from Amaryllidaceae bulbous plants and clustered together as the Amaryllidaceae alkaloids (AAs) family. AAs are specifically remarkable for their diverse pharmaceutical properties, as exemplified by the success of galantamine used to treat the symptoms of Alzheimer’s disease. This review addresses the isolation, biological, and structure activity of AAs discovered from January 2015 to August 2020, supporting their therapeutic interest. MDPI 2020-10-23 /pmc/articles/PMC7660210/ /pubmed/33113950 http://dx.doi.org/10.3390/molecules25214901 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Ka, Seydou
Koirala, Manoj
Mérindol, Natacha
Desgagné-Penix, Isabel
Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids
title Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids
title_full Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids
title_fullStr Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids
title_full_unstemmed Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids
title_short Biosynthesis and Biological Activities of Newly Discovered Amaryllidaceae Alkaloids
title_sort biosynthesis and biological activities of newly discovered amaryllidaceae alkaloids
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660210/
https://www.ncbi.nlm.nih.gov/pubmed/33113950
http://dx.doi.org/10.3390/molecules25214901
work_keys_str_mv AT kaseydou biosynthesisandbiologicalactivitiesofnewlydiscoveredamaryllidaceaealkaloids
AT koiralamanoj biosynthesisandbiologicalactivitiesofnewlydiscoveredamaryllidaceaealkaloids
AT merindolnatacha biosynthesisandbiologicalactivitiesofnewlydiscoveredamaryllidaceaealkaloids
AT desgagnepenixisabel biosynthesisandbiologicalactivitiesofnewlydiscoveredamaryllidaceaealkaloids

Ejemplares similares