Anti-Angiogenic Properties of Ginsenoside Rg3

Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-c...

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Autores principales: Nakhjavani, Maryam, Smith, Eric, Townsend, Amanda R., Price, Timothy J., Hardingham, Jennifer E.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Review
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660320/
https://www.ncbi.nlm.nih.gov/pubmed/33113992
http://dx.doi.org/10.3390/molecules25214905
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author Nakhjavani, Maryam
Smith, Eric
Townsend, Amanda R.
Price, Timothy J.
Hardingham, Jennifer E.
author_facet Nakhjavani, Maryam
Smith, Eric
Townsend, Amanda R.
Price, Timothy J.
Hardingham, Jennifer E.
author_sort Nakhjavani, Maryam
collection PubMed
description Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-cancer properties of Rg3 is the anti-angiogenic action. This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of Rg3 on angiogenesis, and raises the possibility that Rg3 is a prodrug.
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spelling pubmed-76603202020-11-13 Anti-Angiogenic Properties of Ginsenoside Rg3 Nakhjavani, Maryam Smith, Eric Townsend, Amanda R. Price, Timothy J. Hardingham, Jennifer E. Molecules Review Ginsenoside Rg3 (Rg3) is a member of the ginsenoside family of chemicals extracted from Panax ginseng. Like other ginsenosides, Rg3 has two epimers: 20(S)-ginsenoside Rg3 (SRg3) and 20(R)-ginsenoside Rg3 (RRg3). Rg3 is an intriguing molecule due to its anti-cancer properties. One facet of the anti-cancer properties of Rg3 is the anti-angiogenic action. This review describes the controversies on the effects and effective dose range of Rg3, summarizes the evidence on the efficacy of Rg3 on angiogenesis, and raises the possibility that Rg3 is a prodrug. MDPI 2020-10-23 /pmc/articles/PMC7660320/ /pubmed/33113992 http://dx.doi.org/10.3390/molecules25214905 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Review
Nakhjavani, Maryam
Smith, Eric
Townsend, Amanda R.
Price, Timothy J.
Hardingham, Jennifer E.
Anti-Angiogenic Properties of Ginsenoside Rg3
title Anti-Angiogenic Properties of Ginsenoside Rg3
title_full Anti-Angiogenic Properties of Ginsenoside Rg3
title_fullStr Anti-Angiogenic Properties of Ginsenoside Rg3
title_full_unstemmed Anti-Angiogenic Properties of Ginsenoside Rg3
title_short Anti-Angiogenic Properties of Ginsenoside Rg3
title_sort anti-angiogenic properties of ginsenoside rg3
topic Review
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660320/
https://www.ncbi.nlm.nih.gov/pubmed/33113992
http://dx.doi.org/10.3390/molecules25214905
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