Identification of Intrinsic Drug Resistance and Its Biomarkers in High-Throughput Pharmacogenomic and CRISPR Screens

High-throughput drug screens in cancer cell lines test compounds at low concentrations, thereby enabling the identification of drug-sensitivity biomarkers, while resistance biomarkers remain underexplored. Dissecting meaningful drug responses at high concentrations is challenging due to cytotoxicity...

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Detalles Bibliográficos
Autores principales: Ayestaran, Iñigo, Galhoz, Ana, Spiegel, Elmar, Sidders, Ben, Dry, Jonathan R., Dondelinger, Frank, Bender, Andreas, McDermott, Ultan, Iorio, Francesco, Menden, Michael P.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Elsevier 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660407/
https://www.ncbi.nlm.nih.gov/pubmed/33205120
http://dx.doi.org/10.1016/j.patter.2020.100065

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