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The incidence of malignant brain tumors is increased in patients with obstructive sleep apnea: A national health insurance survey
The association between obstructive sleep apnea (OSA) and malignant brain tumors has yet to be fully investigated. Therefore, the purpose of this study was to elucidate the effect of OSA on brain tumor incidence based on the Korea National Health Insurance Service (KNHIS) dataset. The KNHIS data bet...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660473/ https://www.ncbi.nlm.nih.gov/pubmed/33180841 http://dx.doi.org/10.1371/journal.pone.0241598 |
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author | Cho, Jae Hoon Lim, Young Chang Han, Kyung-Do Lee, Jae Yong Choi, Ji Ho |
author_facet | Cho, Jae Hoon Lim, Young Chang Han, Kyung-Do Lee, Jae Yong Choi, Ji Ho |
author_sort | Cho, Jae Hoon |
collection | PubMed |
description | The association between obstructive sleep apnea (OSA) and malignant brain tumors has yet to be fully investigated. Therefore, the purpose of this study was to elucidate the effect of OSA on brain tumor incidence based on the Korea National Health Insurance Service (KNHIS) dataset. The KNHIS data between 2007 and 2014 were analyzed, and the primary endpoint was newly diagnosed malignant brain tumor. A total of 198,574 subjects aged ≥ 20 years with newly diagnosed OSA were enrolled in the study, and 992,870 individuals were selected as a control group based on propensity score matching (PSM) by gender and age. The average follow-up duration was 4.8 ± 2.3 years. The hazard ratios (HRs) for brain tumor for patients with OSA were 1.78 (95% confidence interval [CI]: 1.42–2.21) in Model 1 (not adjusted with any covariate) and 1.67 (95% CI: 1.34–2.09) in Model 2 (adjusted for income level, diabetes, hypertension, dyslipidemia, and COPD). In subgroup analysis by gender, the odds ratios (OR) of OSA were 1.82 (95% CI: 1.41–2.33) in men and 1.26 (95% CI: 0.74–2.03) in women. The ORs were 1.97 (95% CI: 1.15–3.24) in the older (age ≥ 65 years) group, 1.66 (95% CI: 1.25–2.17) in the middle-aged (40 ≤ age < 65 years) group, and 1.41 (0.78–2.44) in the young (20 ≤ age < 40 years) group. In conclusion, OSA may increase the incidence of brain tumors. |
format | Online Article Text |
id | pubmed-7660473 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76604732020-11-18 The incidence of malignant brain tumors is increased in patients with obstructive sleep apnea: A national health insurance survey Cho, Jae Hoon Lim, Young Chang Han, Kyung-Do Lee, Jae Yong Choi, Ji Ho PLoS One Research Article The association between obstructive sleep apnea (OSA) and malignant brain tumors has yet to be fully investigated. Therefore, the purpose of this study was to elucidate the effect of OSA on brain tumor incidence based on the Korea National Health Insurance Service (KNHIS) dataset. The KNHIS data between 2007 and 2014 were analyzed, and the primary endpoint was newly diagnosed malignant brain tumor. A total of 198,574 subjects aged ≥ 20 years with newly diagnosed OSA were enrolled in the study, and 992,870 individuals were selected as a control group based on propensity score matching (PSM) by gender and age. The average follow-up duration was 4.8 ± 2.3 years. The hazard ratios (HRs) for brain tumor for patients with OSA were 1.78 (95% confidence interval [CI]: 1.42–2.21) in Model 1 (not adjusted with any covariate) and 1.67 (95% CI: 1.34–2.09) in Model 2 (adjusted for income level, diabetes, hypertension, dyslipidemia, and COPD). In subgroup analysis by gender, the odds ratios (OR) of OSA were 1.82 (95% CI: 1.41–2.33) in men and 1.26 (95% CI: 0.74–2.03) in women. The ORs were 1.97 (95% CI: 1.15–3.24) in the older (age ≥ 65 years) group, 1.66 (95% CI: 1.25–2.17) in the middle-aged (40 ≤ age < 65 years) group, and 1.41 (0.78–2.44) in the young (20 ≤ age < 40 years) group. In conclusion, OSA may increase the incidence of brain tumors. Public Library of Science 2020-11-12 /pmc/articles/PMC7660473/ /pubmed/33180841 http://dx.doi.org/10.1371/journal.pone.0241598 Text en © 2020 Cho et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Cho, Jae Hoon Lim, Young Chang Han, Kyung-Do Lee, Jae Yong Choi, Ji Ho The incidence of malignant brain tumors is increased in patients with obstructive sleep apnea: A national health insurance survey |
title | The incidence of malignant brain tumors is increased in patients with obstructive sleep apnea: A national health insurance survey |
title_full | The incidence of malignant brain tumors is increased in patients with obstructive sleep apnea: A national health insurance survey |
title_fullStr | The incidence of malignant brain tumors is increased in patients with obstructive sleep apnea: A national health insurance survey |
title_full_unstemmed | The incidence of malignant brain tumors is increased in patients with obstructive sleep apnea: A national health insurance survey |
title_short | The incidence of malignant brain tumors is increased in patients with obstructive sleep apnea: A national health insurance survey |
title_sort | incidence of malignant brain tumors is increased in patients with obstructive sleep apnea: a national health insurance survey |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660473/ https://www.ncbi.nlm.nih.gov/pubmed/33180841 http://dx.doi.org/10.1371/journal.pone.0241598 |
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