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Vaccination strategies on dynamic networks with indirect transmission links and limited contact information

Infectious diseases are still a major global burden for modern society causing 13 million deaths annually. One way to reduce the morbidity and mortality rates from infectious diseases is through pre-emptive or targeted vaccinations. Current theoretical vaccination strategies based on contact network...

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Autores principales: Shahzamal, Md, Mans, Bernard, de Hoog, Frank, Paini, Dean, Jurdak, Raja
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660487/
https://www.ncbi.nlm.nih.gov/pubmed/33180786
http://dx.doi.org/10.1371/journal.pone.0241612
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author Shahzamal, Md
Mans, Bernard
de Hoog, Frank
Paini, Dean
Jurdak, Raja
author_facet Shahzamal, Md
Mans, Bernard
de Hoog, Frank
Paini, Dean
Jurdak, Raja
author_sort Shahzamal, Md
collection PubMed
description Infectious diseases are still a major global burden for modern society causing 13 million deaths annually. One way to reduce the morbidity and mortality rates from infectious diseases is through pre-emptive or targeted vaccinations. Current theoretical vaccination strategies based on contact networks, however, rely on highly specific individual contact information which is difficult and costly to obtain, in order to identify influential spreading individuals. Current approaches also focus only on direct contacts between individuals for spreading, and disregard indirect transmission where a pathogen can spread between one infected individual and one susceptible individual who visit the same location within a short time-frame without meeting. This paper presents a novel vaccination strategy which relies on coarse-grained contact information, both direct and indirect, that can be easily and efficiently collected. Rather than tracking exact contact degrees of individuals, our strategy uses the types of places people visit to estimate a range of contact degrees for individuals, considering both direct and indirect contacts. We conduct extensive computer simulations to evaluate the performance of our strategy in comparison to state-of-the-art vaccination strategies. Results show that, when considering indirect links, our lower cost vaccination strategy achieves comparable performance to the contact-degree based approach and outperforms other existing strategies without requiring over-detailed information.
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spelling pubmed-76604872020-11-18 Vaccination strategies on dynamic networks with indirect transmission links and limited contact information Shahzamal, Md Mans, Bernard de Hoog, Frank Paini, Dean Jurdak, Raja PLoS One Research Article Infectious diseases are still a major global burden for modern society causing 13 million deaths annually. One way to reduce the morbidity and mortality rates from infectious diseases is through pre-emptive or targeted vaccinations. Current theoretical vaccination strategies based on contact networks, however, rely on highly specific individual contact information which is difficult and costly to obtain, in order to identify influential spreading individuals. Current approaches also focus only on direct contacts between individuals for spreading, and disregard indirect transmission where a pathogen can spread between one infected individual and one susceptible individual who visit the same location within a short time-frame without meeting. This paper presents a novel vaccination strategy which relies on coarse-grained contact information, both direct and indirect, that can be easily and efficiently collected. Rather than tracking exact contact degrees of individuals, our strategy uses the types of places people visit to estimate a range of contact degrees for individuals, considering both direct and indirect contacts. We conduct extensive computer simulations to evaluate the performance of our strategy in comparison to state-of-the-art vaccination strategies. Results show that, when considering indirect links, our lower cost vaccination strategy achieves comparable performance to the contact-degree based approach and outperforms other existing strategies without requiring over-detailed information. Public Library of Science 2020-11-12 /pmc/articles/PMC7660487/ /pubmed/33180786 http://dx.doi.org/10.1371/journal.pone.0241612 Text en © 2020 Shahzamal et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Shahzamal, Md
Mans, Bernard
de Hoog, Frank
Paini, Dean
Jurdak, Raja
Vaccination strategies on dynamic networks with indirect transmission links and limited contact information
title Vaccination strategies on dynamic networks with indirect transmission links and limited contact information
title_full Vaccination strategies on dynamic networks with indirect transmission links and limited contact information
title_fullStr Vaccination strategies on dynamic networks with indirect transmission links and limited contact information
title_full_unstemmed Vaccination strategies on dynamic networks with indirect transmission links and limited contact information
title_short Vaccination strategies on dynamic networks with indirect transmission links and limited contact information
title_sort vaccination strategies on dynamic networks with indirect transmission links and limited contact information
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660487/
https://www.ncbi.nlm.nih.gov/pubmed/33180786
http://dx.doi.org/10.1371/journal.pone.0241612
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