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Vaccination strategies on dynamic networks with indirect transmission links and limited contact information
Infectious diseases are still a major global burden for modern society causing 13 million deaths annually. One way to reduce the morbidity and mortality rates from infectious diseases is through pre-emptive or targeted vaccinations. Current theoretical vaccination strategies based on contact network...
Autores principales: | , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660487/ https://www.ncbi.nlm.nih.gov/pubmed/33180786 http://dx.doi.org/10.1371/journal.pone.0241612 |
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author | Shahzamal, Md Mans, Bernard de Hoog, Frank Paini, Dean Jurdak, Raja |
author_facet | Shahzamal, Md Mans, Bernard de Hoog, Frank Paini, Dean Jurdak, Raja |
author_sort | Shahzamal, Md |
collection | PubMed |
description | Infectious diseases are still a major global burden for modern society causing 13 million deaths annually. One way to reduce the morbidity and mortality rates from infectious diseases is through pre-emptive or targeted vaccinations. Current theoretical vaccination strategies based on contact networks, however, rely on highly specific individual contact information which is difficult and costly to obtain, in order to identify influential spreading individuals. Current approaches also focus only on direct contacts between individuals for spreading, and disregard indirect transmission where a pathogen can spread between one infected individual and one susceptible individual who visit the same location within a short time-frame without meeting. This paper presents a novel vaccination strategy which relies on coarse-grained contact information, both direct and indirect, that can be easily and efficiently collected. Rather than tracking exact contact degrees of individuals, our strategy uses the types of places people visit to estimate a range of contact degrees for individuals, considering both direct and indirect contacts. We conduct extensive computer simulations to evaluate the performance of our strategy in comparison to state-of-the-art vaccination strategies. Results show that, when considering indirect links, our lower cost vaccination strategy achieves comparable performance to the contact-degree based approach and outperforms other existing strategies without requiring over-detailed information. |
format | Online Article Text |
id | pubmed-7660487 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76604872020-11-18 Vaccination strategies on dynamic networks with indirect transmission links and limited contact information Shahzamal, Md Mans, Bernard de Hoog, Frank Paini, Dean Jurdak, Raja PLoS One Research Article Infectious diseases are still a major global burden for modern society causing 13 million deaths annually. One way to reduce the morbidity and mortality rates from infectious diseases is through pre-emptive or targeted vaccinations. Current theoretical vaccination strategies based on contact networks, however, rely on highly specific individual contact information which is difficult and costly to obtain, in order to identify influential spreading individuals. Current approaches also focus only on direct contacts between individuals for spreading, and disregard indirect transmission where a pathogen can spread between one infected individual and one susceptible individual who visit the same location within a short time-frame without meeting. This paper presents a novel vaccination strategy which relies on coarse-grained contact information, both direct and indirect, that can be easily and efficiently collected. Rather than tracking exact contact degrees of individuals, our strategy uses the types of places people visit to estimate a range of contact degrees for individuals, considering both direct and indirect contacts. We conduct extensive computer simulations to evaluate the performance of our strategy in comparison to state-of-the-art vaccination strategies. Results show that, when considering indirect links, our lower cost vaccination strategy achieves comparable performance to the contact-degree based approach and outperforms other existing strategies without requiring over-detailed information. Public Library of Science 2020-11-12 /pmc/articles/PMC7660487/ /pubmed/33180786 http://dx.doi.org/10.1371/journal.pone.0241612 Text en © 2020 Shahzamal et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Shahzamal, Md Mans, Bernard de Hoog, Frank Paini, Dean Jurdak, Raja Vaccination strategies on dynamic networks with indirect transmission links and limited contact information |
title | Vaccination strategies on dynamic networks with indirect transmission links and limited contact information |
title_full | Vaccination strategies on dynamic networks with indirect transmission links and limited contact information |
title_fullStr | Vaccination strategies on dynamic networks with indirect transmission links and limited contact information |
title_full_unstemmed | Vaccination strategies on dynamic networks with indirect transmission links and limited contact information |
title_short | Vaccination strategies on dynamic networks with indirect transmission links and limited contact information |
title_sort | vaccination strategies on dynamic networks with indirect transmission links and limited contact information |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660487/ https://www.ncbi.nlm.nih.gov/pubmed/33180786 http://dx.doi.org/10.1371/journal.pone.0241612 |
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