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SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study

Serological surveys have been conducted to establish prevalence for COVID-19 antibodies in various cohorts and communities, reporting a wide range of outcomes. The prevalence of such antibodies among healthcare workers, presumed at higher risk for infection, has been increasingly investigated, more...

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Autores principales: Brant-Zawadzki, Michael, Fridman, Deborah, Robinson, Philip A., Zahn, Matthew, Chau, Clayton, German, Randy, Breit, Marcus, Bock, Jason R., Hara, Junko
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660494/
https://www.ncbi.nlm.nih.gov/pubmed/33180782
http://dx.doi.org/10.1371/journal.pone.0240006
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author Brant-Zawadzki, Michael
Fridman, Deborah
Robinson, Philip A.
Zahn, Matthew
Chau, Clayton
German, Randy
Breit, Marcus
Bock, Jason R.
Hara, Junko
author_facet Brant-Zawadzki, Michael
Fridman, Deborah
Robinson, Philip A.
Zahn, Matthew
Chau, Clayton
German, Randy
Breit, Marcus
Bock, Jason R.
Hara, Junko
author_sort Brant-Zawadzki, Michael
collection PubMed
description Serological surveys have been conducted to establish prevalence for COVID-19 antibodies in various cohorts and communities, reporting a wide range of outcomes. The prevalence of such antibodies among healthcare workers, presumed at higher risk for infection, has been increasingly investigated, more studies are needed to better understand the risks and infection transmission in different healthcare settings. The present study reports on initial sero-surveillance conducted on healthcare workers at a regional hospital system in Orange County, California, during May and June, 2020. Study subjects were recruited from the entire hospital employee workforce and the independent medical staff. Data were collected for job duties and locations, COVID-19 symptoms, a PCR test history, travel record since January 2020, and existence of household contacts with COVID-19. A blood sample was collected from each subject for serum analysis for IgG antibodies to SARS-CoV-2. Of 2,992 tested individuals, a total 2,924 with complete data were included in the analysis. Observed prevalence of 1.06% (31 antibody positive cases), adjusted prevalence of 1.13% for test sensitivity and specificity were identified. Significant group differences between positive vs. negative were observed for age (z = 2.65, p = .008), race (p = .037), presence of fever (p < .001), and loss of smell (p < .001), but not for occupations (p = .710). Possible explanation for this low prevalence includes a relatively low local geographic community prevalence (~4.4%) at the time of testing, the hospital’s timely procurement of personal protective equipment, rigorous employee education, patient triage, and treatment protocol development and implementation. In addition, cross-reactive adaptive T cell mediated immunity, as recently described, may possibly play a greater role in healthcare workers than in the general population.
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spelling pubmed-76604942020-11-18 SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study Brant-Zawadzki, Michael Fridman, Deborah Robinson, Philip A. Zahn, Matthew Chau, Clayton German, Randy Breit, Marcus Bock, Jason R. Hara, Junko PLoS One Research Article Serological surveys have been conducted to establish prevalence for COVID-19 antibodies in various cohorts and communities, reporting a wide range of outcomes. The prevalence of such antibodies among healthcare workers, presumed at higher risk for infection, has been increasingly investigated, more studies are needed to better understand the risks and infection transmission in different healthcare settings. The present study reports on initial sero-surveillance conducted on healthcare workers at a regional hospital system in Orange County, California, during May and June, 2020. Study subjects were recruited from the entire hospital employee workforce and the independent medical staff. Data were collected for job duties and locations, COVID-19 symptoms, a PCR test history, travel record since January 2020, and existence of household contacts with COVID-19. A blood sample was collected from each subject for serum analysis for IgG antibodies to SARS-CoV-2. Of 2,992 tested individuals, a total 2,924 with complete data were included in the analysis. Observed prevalence of 1.06% (31 antibody positive cases), adjusted prevalence of 1.13% for test sensitivity and specificity were identified. Significant group differences between positive vs. negative were observed for age (z = 2.65, p = .008), race (p = .037), presence of fever (p < .001), and loss of smell (p < .001), but not for occupations (p = .710). Possible explanation for this low prevalence includes a relatively low local geographic community prevalence (~4.4%) at the time of testing, the hospital’s timely procurement of personal protective equipment, rigorous employee education, patient triage, and treatment protocol development and implementation. In addition, cross-reactive adaptive T cell mediated immunity, as recently described, may possibly play a greater role in healthcare workers than in the general population. Public Library of Science 2020-11-12 /pmc/articles/PMC7660494/ /pubmed/33180782 http://dx.doi.org/10.1371/journal.pone.0240006 Text en © 2020 Brant-Zawadzki et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Brant-Zawadzki, Michael
Fridman, Deborah
Robinson, Philip A.
Zahn, Matthew
Chau, Clayton
German, Randy
Breit, Marcus
Bock, Jason R.
Hara, Junko
SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study
title SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study
title_full SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study
title_fullStr SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study
title_full_unstemmed SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study
title_short SARS-CoV-2 antibody prevalence in health care workers: Preliminary report of a single center study
title_sort sars-cov-2 antibody prevalence in health care workers: preliminary report of a single center study
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660494/
https://www.ncbi.nlm.nih.gov/pubmed/33180782
http://dx.doi.org/10.1371/journal.pone.0240006
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