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The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways
Inflammation is a vital physiological response of the immune system meant to protect against the invasion of pathogens. However, accumulating evidence describes an intimate link between inflammation and thrombosis and cellular elements of the immune system of the immune system such as neutrophils an...
Autores principales: | , , , , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Public Library of Science
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660536/ https://www.ncbi.nlm.nih.gov/pubmed/33180821 http://dx.doi.org/10.1371/journal.pone.0241607 |
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author | Zhou, Lin Lapping, Stephanie Liao, Xudong Lu, Yuan Zhou, Guangjin Matoba, Keiichiro Vasudevan, Neelakantan Wang, Lemin Nayak, Lalitha |
author_facet | Zhou, Lin Lapping, Stephanie Liao, Xudong Lu, Yuan Zhou, Guangjin Matoba, Keiichiro Vasudevan, Neelakantan Wang, Lemin Nayak, Lalitha |
author_sort | Zhou, Lin |
collection | PubMed |
description | Inflammation is a vital physiological response of the immune system meant to protect against the invasion of pathogens. However, accumulating evidence describes an intimate link between inflammation and thrombosis and cellular elements of the immune system of the immune system such as neutrophils and monocytes/macrophages are emerging as key players in the generation of a prothrombotic milieu suggesting that anti-inflammatory therapy may have a role in the management of thrombosis that is driven by inflammation. Tongji 2 (TJ2) is a traditional Chinese medication manufactured as granules by Tongji hospital of Tongji University (Shanghai, China) with known anti-inflammatory properties. In this study, we examine the effects of TJ2 on inflammation and thrombosis. Our study shows that TJ2 modulates NF-κB activation and thus generates a prominent anti-inflammatory effect. Further, we use mouse models of thrombosis to demonstrate that TJ2 has a beneficial effect in both arterial and venous thrombosis that occurs in the absence of alterations in platelet activation or coagulation. |
format | Online Article Text |
id | pubmed-7660536 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | Public Library of Science |
record_format | MEDLINE/PubMed |
spelling | pubmed-76605362020-11-18 The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways Zhou, Lin Lapping, Stephanie Liao, Xudong Lu, Yuan Zhou, Guangjin Matoba, Keiichiro Vasudevan, Neelakantan Wang, Lemin Nayak, Lalitha PLoS One Research Article Inflammation is a vital physiological response of the immune system meant to protect against the invasion of pathogens. However, accumulating evidence describes an intimate link between inflammation and thrombosis and cellular elements of the immune system of the immune system such as neutrophils and monocytes/macrophages are emerging as key players in the generation of a prothrombotic milieu suggesting that anti-inflammatory therapy may have a role in the management of thrombosis that is driven by inflammation. Tongji 2 (TJ2) is a traditional Chinese medication manufactured as granules by Tongji hospital of Tongji University (Shanghai, China) with known anti-inflammatory properties. In this study, we examine the effects of TJ2 on inflammation and thrombosis. Our study shows that TJ2 modulates NF-κB activation and thus generates a prominent anti-inflammatory effect. Further, we use mouse models of thrombosis to demonstrate that TJ2 has a beneficial effect in both arterial and venous thrombosis that occurs in the absence of alterations in platelet activation or coagulation. Public Library of Science 2020-11-12 /pmc/articles/PMC7660536/ /pubmed/33180821 http://dx.doi.org/10.1371/journal.pone.0241607 Text en © 2020 Zhou et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
spellingShingle | Research Article Zhou, Lin Lapping, Stephanie Liao, Xudong Lu, Yuan Zhou, Guangjin Matoba, Keiichiro Vasudevan, Neelakantan Wang, Lemin Nayak, Lalitha The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways |
title | The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways |
title_full | The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways |
title_fullStr | The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways |
title_full_unstemmed | The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways |
title_short | The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways |
title_sort | thromboprotective effect of traditional chinese medicine tongji 2 granules is dependent on anti-inflammatory activity by suppression of nf-κb pathways |
topic | Research Article |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660536/ https://www.ncbi.nlm.nih.gov/pubmed/33180821 http://dx.doi.org/10.1371/journal.pone.0241607 |
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