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The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways

Inflammation is a vital physiological response of the immune system meant to protect against the invasion of pathogens. However, accumulating evidence describes an intimate link between inflammation and thrombosis and cellular elements of the immune system of the immune system such as neutrophils an...

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Autores principales: Zhou, Lin, Lapping, Stephanie, Liao, Xudong, Lu, Yuan, Zhou, Guangjin, Matoba, Keiichiro, Vasudevan, Neelakantan, Wang, Lemin, Nayak, Lalitha
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660536/
https://www.ncbi.nlm.nih.gov/pubmed/33180821
http://dx.doi.org/10.1371/journal.pone.0241607
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author Zhou, Lin
Lapping, Stephanie
Liao, Xudong
Lu, Yuan
Zhou, Guangjin
Matoba, Keiichiro
Vasudevan, Neelakantan
Wang, Lemin
Nayak, Lalitha
author_facet Zhou, Lin
Lapping, Stephanie
Liao, Xudong
Lu, Yuan
Zhou, Guangjin
Matoba, Keiichiro
Vasudevan, Neelakantan
Wang, Lemin
Nayak, Lalitha
author_sort Zhou, Lin
collection PubMed
description Inflammation is a vital physiological response of the immune system meant to protect against the invasion of pathogens. However, accumulating evidence describes an intimate link between inflammation and thrombosis and cellular elements of the immune system of the immune system such as neutrophils and monocytes/macrophages are emerging as key players in the generation of a prothrombotic milieu suggesting that anti-inflammatory therapy may have a role in the management of thrombosis that is driven by inflammation. Tongji 2 (TJ2) is a traditional Chinese medication manufactured as granules by Tongji hospital of Tongji University (Shanghai, China) with known anti-inflammatory properties. In this study, we examine the effects of TJ2 on inflammation and thrombosis. Our study shows that TJ2 modulates NF-κB activation and thus generates a prominent anti-inflammatory effect. Further, we use mouse models of thrombosis to demonstrate that TJ2 has a beneficial effect in both arterial and venous thrombosis that occurs in the absence of alterations in platelet activation or coagulation.
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spelling pubmed-76605362020-11-18 The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways Zhou, Lin Lapping, Stephanie Liao, Xudong Lu, Yuan Zhou, Guangjin Matoba, Keiichiro Vasudevan, Neelakantan Wang, Lemin Nayak, Lalitha PLoS One Research Article Inflammation is a vital physiological response of the immune system meant to protect against the invasion of pathogens. However, accumulating evidence describes an intimate link between inflammation and thrombosis and cellular elements of the immune system of the immune system such as neutrophils and monocytes/macrophages are emerging as key players in the generation of a prothrombotic milieu suggesting that anti-inflammatory therapy may have a role in the management of thrombosis that is driven by inflammation. Tongji 2 (TJ2) is a traditional Chinese medication manufactured as granules by Tongji hospital of Tongji University (Shanghai, China) with known anti-inflammatory properties. In this study, we examine the effects of TJ2 on inflammation and thrombosis. Our study shows that TJ2 modulates NF-κB activation and thus generates a prominent anti-inflammatory effect. Further, we use mouse models of thrombosis to demonstrate that TJ2 has a beneficial effect in both arterial and venous thrombosis that occurs in the absence of alterations in platelet activation or coagulation. Public Library of Science 2020-11-12 /pmc/articles/PMC7660536/ /pubmed/33180821 http://dx.doi.org/10.1371/journal.pone.0241607 Text en © 2020 Zhou et al http://creativecommons.org/licenses/by/4.0/ This is an open access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/) , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
spellingShingle Research Article
Zhou, Lin
Lapping, Stephanie
Liao, Xudong
Lu, Yuan
Zhou, Guangjin
Matoba, Keiichiro
Vasudevan, Neelakantan
Wang, Lemin
Nayak, Lalitha
The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways
title The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways
title_full The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways
title_fullStr The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways
title_full_unstemmed The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways
title_short The thromboprotective effect of traditional Chinese medicine Tongji 2 granules is dependent on anti-inflammatory activity by suppression of NF-κB pathways
title_sort thromboprotective effect of traditional chinese medicine tongji 2 granules is dependent on anti-inflammatory activity by suppression of nf-κb pathways
topic Research Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660536/
https://www.ncbi.nlm.nih.gov/pubmed/33180821
http://dx.doi.org/10.1371/journal.pone.0241607
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