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In vivo miRNA knockout screening identifies miR-190b as a novel tumor suppressor

MicroRNAs (miRNAs) play important roles in the development of various cancers including lung cancer which is one of the devastating diseases worldwide. How miRNAs function in de novo lung tumorigenesis remains largely unknown. We here developed a CRISPR/Cas9-mediated dual guide RNA (dgRNA) system to...

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Detalles Bibliográficos
Autores principales:	Hong, Hui, Yao, Shun, Zhang, Yuanyuan, Ye, Yi, Li, Cheng, Hu, Liang, Sun, Yihua, Huang, Hsin-Yi, Ji, Hongbin
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Public Library of Science 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660552/ https://www.ncbi.nlm.nih.gov/pubmed/33137086 http://dx.doi.org/10.1371/journal.pgen.1009168

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