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Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers

Paradoxical psoriasis (PP) may occur during treatment with anti-tumor necrosis factor-alpha (TNF-α) drugs in various chronic immune-mediated diseases, mainly inflammatory bowel diseases (IBD) and psoriasis. In this study, clinical and genetic characteristics of PP arising in IBD and psoriatic patien...

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Autores principales: Bucalo, Agostino, Rega, Federica, Zangrilli, Arianna, Silvestri, Valentina, Valentini, Virginia, Scafetta, Giorgia, Marraffa, Federica, Grassi, Sara, Rogante, Elena, Piccolo, Arianna, Cucchiara, Salvatore, Viola, Franca, Bianchi, Luca, Ottini, Laura, Richetta, Antonio
Formato: Online Artículo Texto
Lenguaje:English
Publicado: MDPI 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660646/
https://www.ncbi.nlm.nih.gov/pubmed/33114187
http://dx.doi.org/10.3390/ijms21217873
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author Bucalo, Agostino
Rega, Federica
Zangrilli, Arianna
Silvestri, Valentina
Valentini, Virginia
Scafetta, Giorgia
Marraffa, Federica
Grassi, Sara
Rogante, Elena
Piccolo, Arianna
Cucchiara, Salvatore
Viola, Franca
Bianchi, Luca
Ottini, Laura
Richetta, Antonio
author_facet Bucalo, Agostino
Rega, Federica
Zangrilli, Arianna
Silvestri, Valentina
Valentini, Virginia
Scafetta, Giorgia
Marraffa, Federica
Grassi, Sara
Rogante, Elena
Piccolo, Arianna
Cucchiara, Salvatore
Viola, Franca
Bianchi, Luca
Ottini, Laura
Richetta, Antonio
author_sort Bucalo, Agostino
collection PubMed
description Paradoxical psoriasis (PP) may occur during treatment with anti-tumor necrosis factor-alpha (TNF-α) drugs in various chronic immune-mediated diseases, mainly inflammatory bowel diseases (IBD) and psoriasis. In this study, clinical and genetic characteristics of PP arising in IBD and psoriatic patients were investigated to identify disease-specific markers of the paradoxical effect. A total of 161 IBD and psoriatic patients treated with anti-TNF-α drugs were included in the study. Of these patients, 39 developed PP. All patients were characterized for the main clinical–pathologic characteristics and genotyped for six candidate single nucleotide polymorphisms (SNPs) selected for their possible role in PP susceptibility. In IBD patients, the onset of PP was associated with female sex, presence of comorbidities, and use of adalimumab. IBD patients with PP had a higher frequency of the TNF-α rs1799964 rare allele (p = 0.006) compared with cases without the paradoxical effect, and a lower frequency of the human leucocyte antigen (HLA)-Cw06 rs10484554 rare allele (p = 0.03) compared with psoriatic patients with PP. Overall, these findings point to specific clinical and genetic characteristics of IBD patients with PP and provide data showing that genetic variability may be related to the paradoxical effect of anti-TNF-α drugs with possible implications into clinical practice.
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spelling pubmed-76606462020-11-13 Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers Bucalo, Agostino Rega, Federica Zangrilli, Arianna Silvestri, Valentina Valentini, Virginia Scafetta, Giorgia Marraffa, Federica Grassi, Sara Rogante, Elena Piccolo, Arianna Cucchiara, Salvatore Viola, Franca Bianchi, Luca Ottini, Laura Richetta, Antonio Int J Mol Sci Article Paradoxical psoriasis (PP) may occur during treatment with anti-tumor necrosis factor-alpha (TNF-α) drugs in various chronic immune-mediated diseases, mainly inflammatory bowel diseases (IBD) and psoriasis. In this study, clinical and genetic characteristics of PP arising in IBD and psoriatic patients were investigated to identify disease-specific markers of the paradoxical effect. A total of 161 IBD and psoriatic patients treated with anti-TNF-α drugs were included in the study. Of these patients, 39 developed PP. All patients were characterized for the main clinical–pathologic characteristics and genotyped for six candidate single nucleotide polymorphisms (SNPs) selected for their possible role in PP susceptibility. In IBD patients, the onset of PP was associated with female sex, presence of comorbidities, and use of adalimumab. IBD patients with PP had a higher frequency of the TNF-α rs1799964 rare allele (p = 0.006) compared with cases without the paradoxical effect, and a lower frequency of the human leucocyte antigen (HLA)-Cw06 rs10484554 rare allele (p = 0.03) compared with psoriatic patients with PP. Overall, these findings point to specific clinical and genetic characteristics of IBD patients with PP and provide data showing that genetic variability may be related to the paradoxical effect of anti-TNF-α drugs with possible implications into clinical practice. MDPI 2020-10-23 /pmc/articles/PMC7660646/ /pubmed/33114187 http://dx.doi.org/10.3390/ijms21217873 Text en © 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).
spellingShingle Article
Bucalo, Agostino
Rega, Federica
Zangrilli, Arianna
Silvestri, Valentina
Valentini, Virginia
Scafetta, Giorgia
Marraffa, Federica
Grassi, Sara
Rogante, Elena
Piccolo, Arianna
Cucchiara, Salvatore
Viola, Franca
Bianchi, Luca
Ottini, Laura
Richetta, Antonio
Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers
title Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers
title_full Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers
title_fullStr Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers
title_full_unstemmed Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers
title_short Paradoxical Psoriasis Induced by Anti-TNFα Treatment: Evaluation of Disease-Specific Clinical and Genetic Markers
title_sort paradoxical psoriasis induced by anti-tnfα treatment: evaluation of disease-specific clinical and genetic markers
topic Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660646/
https://www.ncbi.nlm.nih.gov/pubmed/33114187
http://dx.doi.org/10.3390/ijms21217873
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