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Crystal Structure of the Kinase Domain of MerTK in Complex with AZD7762 Provides Clues for Structure-Based Drug Development

Aberrant tyrosine-protein kinase Mer (MerTK) expression triggers prosurvival signaling and contributes to cell survival, invasive motility, and chemoresistance in many kinds of cancers. In addition, recent reports suggested that MerTK could be a primary target for abnormal platelet aggregation. Cons...

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Detalles Bibliográficos
Autores principales:	Park, Tae Hyun, Bae, Seung-Hyun, Bong, Seoung Min, Ryu, Seong Eon, Jang, Hyonchol, Lee, Byung Il
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660649/ https://www.ncbi.nlm.nih.gov/pubmed/33114206 http://dx.doi.org/10.3390/ijms21217878

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