Cargando…

Dual Effect of Soloxolone Methyl on LPS-Induced Inflammation In Vitro and In Vivo

Plant-extracted triterpenoids belong to a class of bioactive compounds with pleotropic functions, including antioxidant, anti-cancer, and anti-inflammatory effects. In this work, we investigated the anti-inflammatory and anti-oxidative activities of a semisynthetic derivative of 18βH-glycyrrhetinic...

Descripción completa

Detalles Bibliográficos
Autores principales:	Markov, Andrey V., Sen’kova, Aleksandra V., Babich, Valeriya O., Odarenko, Kirill V., Talyshev, Vadim A., Salomatina, Oksana V., Salakhutdinov, Nariman F., Zenkova, Marina A., Logashenko, Evgeniya B.
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660695/ https://www.ncbi.nlm.nih.gov/pubmed/33114200 http://dx.doi.org/10.3390/ijms21217876

Ejemplares similares

Cyano Enone-Bearing Triterpenoid Soloxolone Methyl Inhibits Epithelial-Mesenchymal Transition of Human Lung Adenocarcinoma Cells In Vitro and Metastasis of Murine Melanoma In Vivo
por: Markov, Andrey V., et al.
Publicado: (2020)

Soloxolone methyl inhibits influenza virus replication and reduces virus-induced lung inflammation
por: Markov, Andrey V., et al.
Publicado: (2017)

Novel Soloxolone Amides as Potent Anti-Glioblastoma Candidates: Design, Synthesis, In Silico Analysis and Biological Activities In Vitro and In Vivo
por: Markov, Andrey V., et al.
Publicado: (2022)

Soloxolone Methyl Reduces the Stimulatory Effect of Leptin on the Aggressive Phenotype of Murine Neuro2a Neuroblastoma Cells via the MAPK/ERK1/2 Pathway
por: Odarenko, Kirill V., et al.
Publicado: (2023)

Deep insights into the response of human cervical carcinoma cells to a new cyano enone-bearing triterpenoid soloxolone methyl: a transcriptome analysis
por: Markov, Andrey V., et al.
Publicado: (2019)

Novel Epoxides of Soloxolone Methyl: An Effect of the Formation of Oxirane Ring and Stereoisomerism on Cytotoxic Profile, Anti-Metastatic and Anti-Inflammatory Activities In Vitro and In Vivo
por: Salomatina, Oksana V., et al.
Publicado: (2022)

Trioxolone Methyl, a Novel Cyano Enone-Bearing 18βH-Glycyrrhetinic Acid Derivative, Ameliorates Dextran Sulphate Sodium-Induced Colitis in Mice
por: Markov, Andrey V., et al.
Publicado: (2020)

Novel Derivatives of Deoxycholic Acid Bearing Linear Aliphatic Diamine and Aminoalcohol Moieties and their Cyclic Analogs at the C3 Position: Synthesis and Evaluation of Their In Vitro Antitumor Potential
por: Markov, Andrey V., et al.
Publicado: (2019)

Novel 3′-Substituted-1′,2′,4′-Oxadiazole Derivatives of 18βH-Glycyrrhetinic Acid and Their O-Acylated Amidoximes: Synthesis and Evaluation of Antitumor and Anti-Inflammatory Potential In Vitro and In Vivo
por: Markov, Andrey V., et al.
Publicado: (2020)

Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives
por: Logashenko, Evgeniya B, et al.
Publicado: (2011)

Asthma and Post-Asthmatic Fibrosis: A Search for New Promising Molecular Markers of Transition from Acute Inflammation to Pulmonary Fibrosis
por: Savin, Innokenty A., et al.
Publicado: (2022)

Identification of Novel Core Genes Involved in Malignant Transformation of Inflamed Colon Tissue Using a Computational Biology Approach and Verification in Murine Models
por: Markov, Andrey V., et al.
Publicado: (2023)

siRNA-Mediated Timp1 Silencing Inhibited the Inflammatory Phenotype during Acute Lung Injury
por: Chernikov, Ivan V., et al.
Publicado: (2023)

Core genes involved in the regulation of acute lung injury and their association with COVID-19 and tumor progression: A bioinformatics and experimental study
por: Sen’kova, Aleksandra V., et al.
Publicado: (2021)

Bovine Pancreatic RNase A: An Insight into the Mechanism of Antitumor Activity In Vitro and In Vivo
por: Mohamed, Islam Saber Ead, et al.
Publicado: (2022)

Pulmonary Fibrosis as a Result of Acute Lung Inflammation: Molecular Mechanisms, Relevant In Vivo Models, Prognostic and Therapeutic Approaches
por: Savin, Innokenty A., et al.
Publicado: (2022)

Bronchial Asthma, Airway Remodeling and Lung Fibrosis as Successive Steps of One Process
por: Savin, Innokenty A., et al.
Publicado: (2023)

Targeting Circulating SINEs and LINEs with DNase I Provides Metastases Inhibition in Experimental Tumor Models
por: Alekseeva, Ludmila A., et al.
Publicado: (2020)

Drug responsiveness of leukemic cells detected in vitro at diagnosis correlates with therapy response and survival in patients with acute myeloid leukemia
por: Kolesnikova, Maria A., et al.
Publicado: (2021)

Effective Prognostic Model for Therapy Response Prediction in Acute Myeloid Leukemia Patients
por: Kolesnikova, Maria A., et al.
Publicado: (2023)

Dendritic Cell-Derived Artificial Microvesicles Inhibit RLS(40) Lymphosarcoma Growth in Mice via Stimulation of Th1/Th17 Immune Response
por: Markov, Oleg V., et al.
Publicado: (2022)

Human Recombinant DNase I (Pulmozyme(®)) Inhibits Lung Metastases in Murine Metastatic B16 Melanoma Model That Correlates with Restoration of the DNase Activity and the Decrease SINE/LINE and c-Myc Fragments in Blood Cell-Free DNA
por: Alekseeva, Ludmila, et al.
Publicado: (2021)

Single Shot vs. Cocktail: A Comparison of Mono- and Combinative Application of miRNA-Targeted Mesyl Oligonucleotides for Efficient Antitumor Therapy
por: Gaponova, Svetlana, et al.
Publicado: (2022)

Clinical and Prognostic Significance of Cell Sensitivity to Chemotherapy Detected In Vitro on Treatment Response and Survival of Leukemia Patients
por: Kolesnikova, Maria, et al.
Publicado: (2019)

Antitumour Activity of the Ribonuclease Binase from Bacillus pumilus in the RLS(40) Tumour Model Is Associated with the Reorganisation of the miRNA Network and Reversion of Cancer-Related Cascades to Normal Functioning
por: Mohamed, Islam Saber Ead, et al.
Publicado: (2020)

The Toxic Effects of Polychemotherapy onto the Liver Are Accelerated by the Upregulated MDR of Lymphosarcoma
por: Sen'kova, Alexandra V., et al.
Publicado: (2012)

Antitumor and Antimetastatic Effect of Small Immunostimulatory RNA against B16 Melanoma in Mice
por: Kabilova, Tatyana O., et al.
Publicado: (2016)

Immunostimulating RNA Delivered by P1500 PEGylated Cationic Liposomes Limits Influenza Infection in C57Bl/6 Mice
por: Goncharova, Elena P., et al.
Publicado: (2020)

Catalytic Knockdown of miR-21 by Artificial Ribonuclease: Biological Performance in Tumor Model
por: Patutina, Olga A., et al.
Publicado: (2019)

Influence of the Composition of Cationic Liposomes on the Performance of Cargo Immunostimulatory RNA
por: Bishani, Ali, et al.
Publicado: (2023)

New Deoxycholic Acid Derived Tyrosyl-DNA Phosphodiesterase 1 Inhibitors Also Inhibit Tyrosyl-DNA Phosphodiesterase 2
por: Salomatina, Oksana V., et al.
Publicado: (2021)

Autocrine-based selection of ligands for personalized CAR-T therapy of lymphoma
por: Stepanov, Alexey V., et al.
Publicado: (2018)

A practical way to synthesize chiral fluoro-containing polyhydro-2H-chromenes from monoterpenoids
por: Mikhalchenko, Oksana S, et al.
Publicado: (2016)

Novel Semisynthetic Derivatives of Bile Acids as Effective Tyrosyl-DNA Phosphodiesterase 1 Inhibitors
por: Salomatina, Oksana V., et al.
Publicado: (2018)

Molecular and Cellular Mechanisms of Antitumor Immune Response Activation by Dendritic Cells
por: Markov, O. V., et al.
Publicado: (2016)

Antitumor Vaccines Based on Dendritic Cells: From Experiments using Animal Tumor Models to Clinical Trials
por: Markov, O. V., et al.
Publicado: (2017)

Novel 5′-Norcarbocyclic Derivatives of Bicyclic Pyrrolo- and Furano[2,3-d]Pyrimidine Nucleosides
por: Klimenko, Anna A., et al.
Publicado: (2018)

Folate-Equipped Cationic Liposomes Deliver Anti-MDR1-siRNA to the Tumor and Increase the Efficiency of Chemotherapy
por: Gladkikh, Daniil V., et al.
Publicado: (2021)

Prophylactic Dendritic Cell-Based Vaccines Efficiently Inhibit Metastases in Murine Metastatic Melanoma
por: Markov, Oleg V., et al.
Publicado: (2015)

A New Stereoselective Approach to the Substitution of Allyl Hydroxy Group in para-Mentha-1,2-diol in the Search for New Antiparkinsonian Agents
por: Podturkina, Alexandra V., et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_ft41r3n9qvcllvodk6lkj05ngn