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Evolocumab, a PCSK9‐Monoclonal Antibody, Rapidly Reverses Coronary Artery Endothelial Dysfunction in People Living With HIV and People With Dyslipidemia

BACKGROUND: PCSK9 (proprotein convertase subtilisin/kexin type 9) is well recognized for its important role in cholesterol metabolism. Elevated levels are associated with increased cardiovascular risk and inhibition with PCSK9 antibodies (PCSK9i) lowers cardiovascular events in patients with coronar...

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Detalles Bibliográficos
Autores principales: Leucker, Thorsten M., Gerstenblith, Gary, Schär, Michael, Brown, Todd T., Jones, Steven R., Afework, Yohannes, Weiss, Robert G., Hays, Allison G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660736/
https://www.ncbi.nlm.nih.gov/pubmed/32674634
http://dx.doi.org/10.1161/JAHA.120.016263