Ruthenium-Catalyzed trans-Hydroalkynylation and trans-Chloroalkynylation of Internal Alkynes

[Image: see text] [Cp*RuCl](4) catalyzes the addition of iPr(3)SiC≡CX (X = H, Cl) across internal alkynes with formation of 1,3-enyne or 1-chloro-1,3-enyne derivatives, respectively; the reaction follows an unorthodox trans-addition mode. The well-balanced affinities of the different reaction partne...

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Autores principales: Barsu, Nagaraju, Leutzsch, Markus, Fürstner, Alois
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660751/
https://www.ncbi.nlm.nih.gov/pubmed/33095568
http://dx.doi.org/10.1021/jacs.0c08582
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author Barsu, Nagaraju
Leutzsch, Markus
Fürstner, Alois
author_facet Barsu, Nagaraju
Leutzsch, Markus
Fürstner, Alois
author_sort Barsu, Nagaraju
collection PubMed
description [Image: see text] [Cp*RuCl](4) catalyzes the addition of iPr(3)SiC≡CX (X = H, Cl) across internal alkynes with formation of 1,3-enyne or 1-chloro-1,3-enyne derivatives, respectively; the reaction follows an unorthodox trans-addition mode. The well-balanced affinities of the different reaction partners to the ruthenium catalyst ensure that crossed addition prevails over homodimerization of the individual components, as can be deduced from spectroscopic and crystallographic data of various intermediates; this includes a dinuclear complex in which an internal alkyne bridges two [Cp*RuCl] fragments.
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spelling pubmed-76607512020-11-13 Ruthenium-Catalyzed trans-Hydroalkynylation and trans-Chloroalkynylation of Internal Alkynes Barsu, Nagaraju Leutzsch, Markus Fürstner, Alois J Am Chem Soc [Image: see text] [Cp*RuCl](4) catalyzes the addition of iPr(3)SiC≡CX (X = H, Cl) across internal alkynes with formation of 1,3-enyne or 1-chloro-1,3-enyne derivatives, respectively; the reaction follows an unorthodox trans-addition mode. The well-balanced affinities of the different reaction partners to the ruthenium catalyst ensure that crossed addition prevails over homodimerization of the individual components, as can be deduced from spectroscopic and crystallographic data of various intermediates; this includes a dinuclear complex in which an internal alkyne bridges two [Cp*RuCl] fragments. American Chemical Society 2020-10-23 2020-11-04 /pmc/articles/PMC7660751/ /pubmed/33095568 http://dx.doi.org/10.1021/jacs.0c08582 Text en © 2020 American Chemical Society This is an open access article published under a Creative Commons Attribution (CC-BY) License (http://pubs.acs.org/page/policy/authorchoice_ccby_termsofuse.html) , which permits unrestricted use, distribution and reproduction in any medium, provided the author and source are cited.
spellingShingle Barsu, Nagaraju
Leutzsch, Markus
Fürstner, Alois
Ruthenium-Catalyzed trans-Hydroalkynylation and trans-Chloroalkynylation of Internal Alkynes
title Ruthenium-Catalyzed trans-Hydroalkynylation and trans-Chloroalkynylation of Internal Alkynes
title_full Ruthenium-Catalyzed trans-Hydroalkynylation and trans-Chloroalkynylation of Internal Alkynes
title_fullStr Ruthenium-Catalyzed trans-Hydroalkynylation and trans-Chloroalkynylation of Internal Alkynes
title_full_unstemmed Ruthenium-Catalyzed trans-Hydroalkynylation and trans-Chloroalkynylation of Internal Alkynes
title_short Ruthenium-Catalyzed trans-Hydroalkynylation and trans-Chloroalkynylation of Internal Alkynes
title_sort ruthenium-catalyzed trans-hydroalkynylation and trans-chloroalkynylation of internal alkynes
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660751/
https://www.ncbi.nlm.nih.gov/pubmed/33095568
http://dx.doi.org/10.1021/jacs.0c08582
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AT leutzschmarkus rutheniumcatalyzedtranshydroalkynylationandtranschloroalkynylationofinternalalkynes
AT furstneralois rutheniumcatalyzedtranshydroalkynylationandtranschloroalkynylationofinternalalkynes

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