Knockout of SORBS2 Protein Disrupts the Structural Integrity of Intercalated Disc and Manifests Features of Arrhythmogenic Cardiomyopathy

BACKGROUND: Sorbs2b (sorbin and SH3 domain‐containing 2b) was recently identified as a cardiomyopathy gene from a zebrafish mutagenesis screen. However, cardiac functions of its mammalian ortholog remain elusive. METHODS AND RESULTS: We conducted a detailed expression and subcellular localization an...

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Detalles Bibliográficos
Autores principales: Ding, Yonghe, Yang, Jingchun, Chen, Peng, Lu, Tong, Jiao, Kunli, Tester, David J., Giudicessi, John R., Jiang, Kai, Ackerman, Michael J., Li, Yigang, Wang, Dao Wu, Lee, HoN‐chi, Wang, Dao Wen, Xu, Xiaolei
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660791/
https://www.ncbi.nlm.nih.gov/pubmed/32808564
http://dx.doi.org/10.1161/JAHA.119.017055

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