Cargando…

Evaluation of Biventricular Functions in Transplanted Hearts Using 3‐Dimensional Speckle‐Tracking Echocardiography

BACKGROUND: The current study aims to validate the accuracy of 3‐dimensional speckle‐tracking echocardiography (3D‐STE) in evaluating biventricular functions against the accuracy of cardiac magnetic resonance (CMR) and to explore the comprehensive characteristics and normal values for 3D‐biventricul...

Descripción completa

Detalles Bibliográficos
Autores principales: Lv, Qing, Sun, Wei, Wang, Jing, Wu, Chun, Li, He, Shen, Xuehua, Liang, Bo, Dong, Nianguo, Li, Yuman, Zhang, Li, Xie, Mingxing
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660853/
https://www.ncbi.nlm.nih.gov/pubmed/32370590
http://dx.doi.org/10.1161/JAHA.119.015742
_version_ 1783609097327738880
author Lv, Qing
Sun, Wei
Wang, Jing
Wu, Chun
Li, He
Shen, Xuehua
Liang, Bo
Dong, Nianguo
Li, Yuman
Zhang, Li
Xie, Mingxing
author_facet Lv, Qing
Sun, Wei
Wang, Jing
Wu, Chun
Li, He
Shen, Xuehua
Liang, Bo
Dong, Nianguo
Li, Yuman
Zhang, Li
Xie, Mingxing
author_sort Lv, Qing
collection PubMed
description BACKGROUND: The current study aims to validate the accuracy of 3‐dimensional speckle‐tracking echocardiography (3D‐STE) in evaluating biventricular functions against the accuracy of cardiac magnetic resonance (CMR) and to explore the comprehensive characteristics and normal values for 3D‐biventricular functions in transplanted hearts. METHODS AND RESULTS: A cohort of 35 heart transplant (HT) patients underwent both 3D echocardiography and CMR examination to validate the accuracy of 3D‐STE in evaluating biventricular functions (Protocol 1). Then, 3D‐STE derived biventricular functions were compared between 46 HT patients and 46 non‐HT controls (Protocol 2). Protocol 1, validated that 3D‐STE showed excellent accuracy in evaluating biventricular functions of transplanted hearts against CMR. Protocol 2, revealed lower (normal range) 3D‐biventricular ejection fractions in HT patients than in controls (P<0.001). 3D‐left ventricular global longitudinal strain, left ventricular‐global circumferential strain, left ventricular‐global radial strain, left ventricular‐global performance index and right ventricular free‐wall longitudinal strain were all lower in the HT patients than in healthy controls (P<0.001). Further, these strain values were all good for differentiating between groups (areas under the curve: 0.80–0.94, P<0.001). Moreover, left ventricular‐lateral‐wall radial displacement was higher and septal‐wall radial displacement was lower in the HT group than in control group (P<0.001). CONCLUSIONS: Compared with cardiac magnetic resonance, 3D‐STE can evaluate biventricular functions of transplanted hearts accurately; 3D‐biventricular mechanical functions are reduced even in clinically well HT patients. The provided characteristics and appropriate normal values of biventricular functions can be the basis for detection of ventricular dysfunction during follow‐ups and further studies on transplanted hearts.
format Online
Article
Text
id pubmed-7660853
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher John Wiley and Sons Inc.
record_format MEDLINE/PubMed
spelling pubmed-76608532020-11-17 Evaluation of Biventricular Functions in Transplanted Hearts Using 3‐Dimensional Speckle‐Tracking Echocardiography Lv, Qing Sun, Wei Wang, Jing Wu, Chun Li, He Shen, Xuehua Liang, Bo Dong, Nianguo Li, Yuman Zhang, Li Xie, Mingxing J Am Heart Assoc Original Research BACKGROUND: The current study aims to validate the accuracy of 3‐dimensional speckle‐tracking echocardiography (3D‐STE) in evaluating biventricular functions against the accuracy of cardiac magnetic resonance (CMR) and to explore the comprehensive characteristics and normal values for 3D‐biventricular functions in transplanted hearts. METHODS AND RESULTS: A cohort of 35 heart transplant (HT) patients underwent both 3D echocardiography and CMR examination to validate the accuracy of 3D‐STE in evaluating biventricular functions (Protocol 1). Then, 3D‐STE derived biventricular functions were compared between 46 HT patients and 46 non‐HT controls (Protocol 2). Protocol 1, validated that 3D‐STE showed excellent accuracy in evaluating biventricular functions of transplanted hearts against CMR. Protocol 2, revealed lower (normal range) 3D‐biventricular ejection fractions in HT patients than in controls (P<0.001). 3D‐left ventricular global longitudinal strain, left ventricular‐global circumferential strain, left ventricular‐global radial strain, left ventricular‐global performance index and right ventricular free‐wall longitudinal strain were all lower in the HT patients than in healthy controls (P<0.001). Further, these strain values were all good for differentiating between groups (areas under the curve: 0.80–0.94, P<0.001). Moreover, left ventricular‐lateral‐wall radial displacement was higher and septal‐wall radial displacement was lower in the HT group than in control group (P<0.001). CONCLUSIONS: Compared with cardiac magnetic resonance, 3D‐STE can evaluate biventricular functions of transplanted hearts accurately; 3D‐biventricular mechanical functions are reduced even in clinically well HT patients. The provided characteristics and appropriate normal values of biventricular functions can be the basis for detection of ventricular dysfunction during follow‐ups and further studies on transplanted hearts. John Wiley and Sons Inc. 2020-05-06 /pmc/articles/PMC7660853/ /pubmed/32370590 http://dx.doi.org/10.1161/JAHA.119.015742 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made.
spellingShingle Original Research
Lv, Qing
Sun, Wei
Wang, Jing
Wu, Chun
Li, He
Shen, Xuehua
Liang, Bo
Dong, Nianguo
Li, Yuman
Zhang, Li
Xie, Mingxing
Evaluation of Biventricular Functions in Transplanted Hearts Using 3‐Dimensional Speckle‐Tracking Echocardiography
title Evaluation of Biventricular Functions in Transplanted Hearts Using 3‐Dimensional Speckle‐Tracking Echocardiography
title_full Evaluation of Biventricular Functions in Transplanted Hearts Using 3‐Dimensional Speckle‐Tracking Echocardiography
title_fullStr Evaluation of Biventricular Functions in Transplanted Hearts Using 3‐Dimensional Speckle‐Tracking Echocardiography
title_full_unstemmed Evaluation of Biventricular Functions in Transplanted Hearts Using 3‐Dimensional Speckle‐Tracking Echocardiography
title_short Evaluation of Biventricular Functions in Transplanted Hearts Using 3‐Dimensional Speckle‐Tracking Echocardiography
title_sort evaluation of biventricular functions in transplanted hearts using 3‐dimensional speckle‐tracking echocardiography
topic Original Research
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660853/
https://www.ncbi.nlm.nih.gov/pubmed/32370590
http://dx.doi.org/10.1161/JAHA.119.015742
work_keys_str_mv AT lvqing evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT sunwei evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT wangjing evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT wuchun evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT lihe evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT shenxuehua evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT liangbo evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT dongnianguo evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT liyuman evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT zhangli evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography
AT xiemingxing evaluationofbiventricularfunctionsintransplantedheartsusing3dimensionalspeckletrackingechocardiography