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Heterogeneity of Treatment and Outcomes Among Asians With Coronary Artery Disease in the United States
BACKGROUND: Prior data demonstrate significant heterogeneity regarding coronary artery disease risk factors and outcomes among Asians in the United States, but no studies have yet examined coronary artery disease treatment patterns or outcomes among disaggregated Asian American subgroups. METHODS AN...
Autores principales: | , , , , , |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
John Wiley and Sons Inc.
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660869/ https://www.ncbi.nlm.nih.gov/pubmed/32390539 http://dx.doi.org/10.1161/JAHA.119.014362 |
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author | Manjunath, Lakshman Chung, Sukyung Li, Jiang Shah, Harsh Palaniappan, Latha Yong, Celina M. |
author_facet | Manjunath, Lakshman Chung, Sukyung Li, Jiang Shah, Harsh Palaniappan, Latha Yong, Celina M. |
author_sort | Manjunath, Lakshman |
collection | PubMed |
description | BACKGROUND: Prior data demonstrate significant heterogeneity regarding coronary artery disease risk factors and outcomes among Asians in the United States, but no studies have yet examined coronary artery disease treatment patterns or outcomes among disaggregated Asian American subgroups. METHODS AND RESULTS: From a total of 772 882 patients with known race/ethnicity and sex who received care from a mixed‐payer healthcare organization in Northern California between 2006 and 2015, a retrospective analysis was conducted on 6667 adults with coronary artery disease. Logistic regression was used to examine medical and procedural therapies and outcomes by race/ethnicity, with adjustment for age, sex, income, and baseline comorbidities. Compared with non‐Hispanic whites, Chinese were more likely to undergo stenting (50.9% versus 60.8%, odds ratio [OR] 1.39 [95% CI, 1.04–1.87], p=0.005), whereas Filipinos were more likely to receive bypass surgery (6.9% versus 20.5%, OR 2.65 [95% CI, 1.75–4.01], P<0.0001). After stenting, Chinese, Filipinos, and Japanese were more likely than non‐Hispanic whites to be prescribed clopidogrel (86.2%, 83.0%, and 91.4% versus 74.5%, ORs 1.86 [95% CI, 1.13–3.04], 1.86 [95% CI, 1.01–3.44], and 4.37 [95% CI, 1.02–18.67], respectively, P<0.0001). Lastly, Chinese and Asian Indians were more likely than non‐Hispanic whites to be diagnosed with a myocardial infarction within 1 year postangiography (15.6% and 17.4% versus 11.2%, ORs 1.49 [95% CI, 1.02–2.19] and 1.68 [95% CI, 1.21–2.34], respectively, P<0.0001). CONCLUSIONS: Disaggregation of Asian Americans with coronary artery disease into individual racial/ethnic subgroups reveals significant variability in treatment patterns and outcomes. Further investigation into these differences may expose important opportunities to mitigate disparities and improve quality of care in this diverse population. |
format | Online Article Text |
id | pubmed-7660869 |
institution | National Center for Biotechnology Information |
language | English |
publishDate | 2020 |
publisher | John Wiley and Sons Inc. |
record_format | MEDLINE/PubMed |
spelling | pubmed-76608692020-11-17 Heterogeneity of Treatment and Outcomes Among Asians With Coronary Artery Disease in the United States Manjunath, Lakshman Chung, Sukyung Li, Jiang Shah, Harsh Palaniappan, Latha Yong, Celina M. J Am Heart Assoc Original Research BACKGROUND: Prior data demonstrate significant heterogeneity regarding coronary artery disease risk factors and outcomes among Asians in the United States, but no studies have yet examined coronary artery disease treatment patterns or outcomes among disaggregated Asian American subgroups. METHODS AND RESULTS: From a total of 772 882 patients with known race/ethnicity and sex who received care from a mixed‐payer healthcare organization in Northern California between 2006 and 2015, a retrospective analysis was conducted on 6667 adults with coronary artery disease. Logistic regression was used to examine medical and procedural therapies and outcomes by race/ethnicity, with adjustment for age, sex, income, and baseline comorbidities. Compared with non‐Hispanic whites, Chinese were more likely to undergo stenting (50.9% versus 60.8%, odds ratio [OR] 1.39 [95% CI, 1.04–1.87], p=0.005), whereas Filipinos were more likely to receive bypass surgery (6.9% versus 20.5%, OR 2.65 [95% CI, 1.75–4.01], P<0.0001). After stenting, Chinese, Filipinos, and Japanese were more likely than non‐Hispanic whites to be prescribed clopidogrel (86.2%, 83.0%, and 91.4% versus 74.5%, ORs 1.86 [95% CI, 1.13–3.04], 1.86 [95% CI, 1.01–3.44], and 4.37 [95% CI, 1.02–18.67], respectively, P<0.0001). Lastly, Chinese and Asian Indians were more likely than non‐Hispanic whites to be diagnosed with a myocardial infarction within 1 year postangiography (15.6% and 17.4% versus 11.2%, ORs 1.49 [95% CI, 1.02–2.19] and 1.68 [95% CI, 1.21–2.34], respectively, P<0.0001). CONCLUSIONS: Disaggregation of Asian Americans with coronary artery disease into individual racial/ethnic subgroups reveals significant variability in treatment patterns and outcomes. Further investigation into these differences may expose important opportunities to mitigate disparities and improve quality of care in this diverse population. John Wiley and Sons Inc. 2020-05-11 /pmc/articles/PMC7660869/ /pubmed/32390539 http://dx.doi.org/10.1161/JAHA.119.014362 Text en © 2020 The Authors. Published on behalf of the American Heart Association, Inc., by Wiley. This is an open access article under the terms of the http://creativecommons.org/licenses/by-nc-nd/4.0/ License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non‐commercial and no modifications or adaptations are made. |
spellingShingle | Original Research Manjunath, Lakshman Chung, Sukyung Li, Jiang Shah, Harsh Palaniappan, Latha Yong, Celina M. Heterogeneity of Treatment and Outcomes Among Asians With Coronary Artery Disease in the United States |
title | Heterogeneity of Treatment and Outcomes Among Asians With Coronary Artery Disease in the United States |
title_full | Heterogeneity of Treatment and Outcomes Among Asians With Coronary Artery Disease in the United States |
title_fullStr | Heterogeneity of Treatment and Outcomes Among Asians With Coronary Artery Disease in the United States |
title_full_unstemmed | Heterogeneity of Treatment and Outcomes Among Asians With Coronary Artery Disease in the United States |
title_short | Heterogeneity of Treatment and Outcomes Among Asians With Coronary Artery Disease in the United States |
title_sort | heterogeneity of treatment and outcomes among asians with coronary artery disease in the united states |
topic | Original Research |
url | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660869/ https://www.ncbi.nlm.nih.gov/pubmed/32390539 http://dx.doi.org/10.1161/JAHA.119.014362 |
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