The prefoldin complex stabilizes the von Hippel-Lindau protein against aggregation and degradation

Loss of von Hippel-Lindau protein pVHL function promotes VHL diseases, including sporadic and inherited clear cell Renal Cell Carcinoma (ccRCC). Mechanisms controlling pVHL function and regulation, including folding and stability, remain elusive. Here, we have identified the conserved cochaperone pr...

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Detalles Bibliográficos
Autores principales: Chesnel, Franck, Couturier, Anne, Alusse, Adrien, Gagné, Jean-Philippe, Poirier, Guy G., Jean, Dominique, Boisvert, François-Michel, Hascoet, Pauline, Paillard, Luc, Arlot-Bonnemains, Yannick, Le Goff, Xavier
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7660911/
https://www.ncbi.nlm.nih.gov/pubmed/33137104
http://dx.doi.org/10.1371/journal.pgen.1009183

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