Increased mTOR activity and metabolic efficiency in mouse and human cells containing the African-centric tumor-predisposing p53 variant Pro47Ser

The Pro47Ser variant of p53 (S47) exists in African-descent populations and is associated with increased cancer risk in humans and mice. Due to impaired repression of the cystine importer Slc7a11, S47 cells show increased glutathione (GSH) accumulation compared to cells with wild -type p53. We show...

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Detalles Bibliográficos
Autores principales: Gnanapradeepan, Keerthana, Leu, Julia I-Ju, Basu, Subhasree, Barnoud, Thibaut, Good, Madeline, Lee, Joyce V, Quinn, William J, Kung, Che-Pei, Ahima, Rexford, Baur, Joseph A, Wellen, Kathryn E, Liu, Qin, Schug, Zachary T, George, Donna L, Murphy, Maureen E
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661039/
https://www.ncbi.nlm.nih.gov/pubmed/33170774
http://dx.doi.org/10.7554/eLife.55994

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