Inhibiting IRE1α-endonuclease activity decreases tumor burden in a mouse model for hepatocellular carcinoma

Hepatocellular carcinoma (HCC) is a liver tumor that usually arises in patients with cirrhosis. Hepatic stellate cells are key players in the progression of HCC, as they create a fibrotic micro-environment and produce growth factors and cytokines that enhance tumor cell proliferation and migration....

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Detalles Bibliográficos
Autores principales: Pavlović, Nataša, Calitz, Carlemi, Thanapirom, Kess, Mazza, Guiseppe, Rombouts, Krista, Gerwins, Pär, Heindryckx, Femke
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Cancer Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661042/
https://www.ncbi.nlm.nih.gov/pubmed/33103995
http://dx.doi.org/10.7554/eLife.55865

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661042/
https://www.ncbi.nlm.nih.gov/pubmed/33103995
http://dx.doi.org/10.7554/eLife.55865

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