CircR2Cancer: a manually curated database of associations between circRNAs and cancers

Accumulating evidences have shown that the deregulation of circRNA has close association with many human cancers. However, these experimental verified circRNA–cancer associations are not collected in any database. Here, we develop a manually curated database (circR2Cancer) that provides experimental...

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Detalles Bibliográficos
Autores principales: Lan, Wei, Zhu, Mingrui, Chen, Qingfeng, Chen, Baoshan, Liu, Jin, Li, Min, Chen, Yi-Ping Phoebe
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661096/
https://www.ncbi.nlm.nih.gov/pubmed/33181824
http://dx.doi.org/10.1093/database/baaa085
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author Lan, Wei
Zhu, Mingrui
Chen, Qingfeng
Chen, Baoshan
Liu, Jin
Li, Min
Chen, Yi-Ping Phoebe
author_facet Lan, Wei
Zhu, Mingrui
Chen, Qingfeng
Chen, Baoshan
Liu, Jin
Li, Min
Chen, Yi-Ping Phoebe
author_sort Lan, Wei
collection PubMed
description Accumulating evidences have shown that the deregulation of circRNA has close association with many human cancers. However, these experimental verified circRNA–cancer associations are not collected in any database. Here, we develop a manually curated database (circR2Cancer) that provides experimentally supported associations between circRNAs and cancers. The current version of the circR2Cancer contains 1439 associations between 1135 circRNAs and 82 cancers by extracting data from existing literatures and databases. In addition, circR2Cancer contains the information of cancer exacted from Disease Ontology and basic biological information of circRNAs from circBase. At the same time, circR2Cancer provides a simple and friendly interface for users to conveniently browse, search and download the data. It will be a useful and valuable resource for researchers to understanding the regulation mechanism of circRNA in cancers. DATABASE URL: http://www.biobdlab.cn:8000
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spelling pubmed-76610962020-11-18 CircR2Cancer: a manually curated database of associations between circRNAs and cancers Lan, Wei Zhu, Mingrui Chen, Qingfeng Chen, Baoshan Liu, Jin Li, Min Chen, Yi-Ping Phoebe Database (Oxford) Original Article Accumulating evidences have shown that the deregulation of circRNA has close association with many human cancers. However, these experimental verified circRNA–cancer associations are not collected in any database. Here, we develop a manually curated database (circR2Cancer) that provides experimentally supported associations between circRNAs and cancers. The current version of the circR2Cancer contains 1439 associations between 1135 circRNAs and 82 cancers by extracting data from existing literatures and databases. In addition, circR2Cancer contains the information of cancer exacted from Disease Ontology and basic biological information of circRNAs from circBase. At the same time, circR2Cancer provides a simple and friendly interface for users to conveniently browse, search and download the data. It will be a useful and valuable resource for researchers to understanding the regulation mechanism of circRNA in cancers. DATABASE URL: http://www.biobdlab.cn:8000 Oxford University Press 2020-11-11 /pmc/articles/PMC7661096/ /pubmed/33181824 http://dx.doi.org/10.1093/database/baaa085 Text en © The Author(s) 2020. Published by Oxford University Press. http://creativecommons.org/licenses/by/4.0/ This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
spellingShingle Original Article
Lan, Wei
Zhu, Mingrui
Chen, Qingfeng
Chen, Baoshan
Liu, Jin
Li, Min
Chen, Yi-Ping Phoebe
CircR2Cancer: a manually curated database of associations between circRNAs and cancers
title CircR2Cancer: a manually curated database of associations between circRNAs and cancers
title_full CircR2Cancer: a manually curated database of associations between circRNAs and cancers
title_fullStr CircR2Cancer: a manually curated database of associations between circRNAs and cancers
title_full_unstemmed CircR2Cancer: a manually curated database of associations between circRNAs and cancers
title_short CircR2Cancer: a manually curated database of associations between circRNAs and cancers
title_sort circr2cancer: a manually curated database of associations between circrnas and cancers
topic Original Article
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661096/
https://www.ncbi.nlm.nih.gov/pubmed/33181824
http://dx.doi.org/10.1093/database/baaa085
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