Cargando…

Mechanism of Abnormal Chondrocyte Proliferation Induced by Piezo1-siRNA Exposed to Mechanical Stretch

OBJECTIVE: To investigate the effect of small interfering RNA targeting mechanosensitive ion channel protein Piezo1 (Piezo1-siRNA) on abnormal chondrocyte proliferation exposed to mechanical stretch. METHODS: Construct and screen effective Piezo1-siRNA sequences and explore an appropriate method to...

Descripción completa

Detalles Bibliográficos
Autores principales:	Sun, Yi, Leng, Ping, Li, Dawei, Gao, Huanshen, Li, Zhenghui, Li, Chenkai, Zhang, Haining
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Hindawi 2020
Materias:	Research Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661139/ https://www.ncbi.nlm.nih.gov/pubmed/33204718 http://dx.doi.org/10.1155/2020/8538463

Ejemplares similares

G protein coupled estrogen receptor attenuates mechanical stress-mediated apoptosis of chondrocyte in osteoarthritis via suppression of Piezo1
por: Sun, Yi, et al.
Publicado: (2021)

Mechanical regulation of stem cell differentiation through stretch-activated Piezo channel
por: He, Li, et al.
Publicado: (2018)

Microscopic mechanism of PIEZO1 activation by pressure-induced membrane stretch
por: Wijerathne, Tharaka D., et al.
Publicado: (2023)

Mechanical stretch promotes hypertrophic scar formation through mechanically activated cation channel Piezo1
por: He, Jiahao, et al.
Publicado: (2021)

Mechanical Stretch Triggers Epithelial-Mesenchymal Transition in Keratinocytes Through Piezo1 Channel
por: He, Jiahao, et al.
Publicado: (2022)

Mechanical stretching induces fibroblasts apoptosis through activating Piezo1 and then destroying actin cytoskeleton
por: Li, Yang, et al.
Publicado: (2023)

Mechanical Stretching Simulates Cardiac Physiology and Pathology through Mechanosensor Piezo1
por: Wong, Tzyy-Yue, et al.
Publicado: (2018)

Mechanical stretch triggers rapid epithelial cell division through Piezo1
por: Gudipaty, SA, et al.
Publicado: (2017)

The Mechanism for siRNA Transmembrane Assisted by PMAL
por: Lu, Yanfei, et al.
Publicado: (2018)

Mechanical Stretch Promotes Hypertrophic Scars Formation Through Mechanically Activated Ion Channel Piezo1
por: He, Jiahao, et al.
Publicado: (2020)

The Role of Mechanically-Activated Ion Channels Piezo1, Piezo2, and TRPV4 in Chondrocyte Mechanotransduction and Mechano-Therapeutics for Osteoarthritis
por: Gao, Winni, et al.
Publicado: (2022)

Molecular Mechanisms of Chondrocyte Proliferation and Differentiation
por: Chen, Hui, et al.
Publicado: (2021)

Mechanical stretch scales centriole number to apical area via Piezo1 in multiciliated cells
por: Kulkarni, Saurabh, et al.
Publicado: (2021)

Molecular Mechanisms and Biological Functions of siRNA
por: Dana, Hassan, et al.
Publicado: (2017)

Remodeling of an in vitro microvessel exposed to cyclic mechanical stretch
por: Zeinali, Soheila, et al.
Publicado: (2021)

Mechanism of siRNA production from repetitive DNA
por: Yang, Qiuying, et al.
Publicado: (2015)

RNA-based scaffolds for bone regeneration: application and mechanisms of mRNA, miRNA and siRNA
por: Leng, Qiuping, et al.
Publicado: (2020)

Mechanical overloading induces GPX4-regulated chondrocyte ferroptosis in osteoarthritis via Piezo1 channel facilitated calcium influx
por: Wang, Shaoyi, et al.
Publicado: (2022)

p66shc siRNA Nanoparticles Ameliorate Chondrocytic Mitochondrial Dysfunction in Osteoarthritis
por: Shin, Hyo Jung, et al.
Publicado: (2020)

Mechanisms of PIEZO Channel Inactivation
por: Zhou, Zijing, et al.
Publicado: (2023)

Inflammatory signaling sensitizes Piezo1 mechanotransduction in articular chondrocytes as a pathogenic feed-forward mechanism in osteoarthritis
por: Lee, Whasil, et al.
Publicado: (2021)

Mechanisms and strategies for effective delivery of antisense and siRNA oligonucleotides
por: Juliano, Rudy, et al.
Publicado: (2008)

Molecular Properties, Functional Mechanisms, and Applications of Sliced siRNA
por: Sun, Guihua, et al.
Publicado: (2015)

Effects of cyclic equibiaxial mechanical stretch on α-BK and TRPV4 expression in equine chondrocytes
por: Hdud, Ismail M, et al.
Publicado: (2014)

Mechanical study of the Saclay piezo tuner Â» PTS (Piezo Tuning System)
por: Bosland, P, et al.
Publicado: (2005)

The role of Drosophila Piezo in mechanical nociception
por: Kim, Sung Eun, et al.
Publicado: (2012)

Design, mechanism, delivery and therapeutics of canonical and Dicer-substrate siRNA
por: Raja, Maria Abdul Ghafoor, et al.
Publicado: (2019)

Harnessing a Physiologic Mechanism for siRNA Delivery With Mimetic Lipoprotein Particles
por: Nakayama, Tomoko, et al.
Publicado: (2012)

TRPV4 and PIEZO Channels Mediate the Mechanosensing of Chondrocytes to the Biomechanical Microenvironment
por: Zhang, Min, et al.
Publicado: (2022)

Coupling Langevin Dynamics With Continuum Mechanics: Exposing the Role of Sarcomere Stretch Activation Mechanisms to Cardiac Function
por: Washio, Takumi, et al.
Publicado: (2018)

PYGB siRNA inhibits the cell proliferation of human osteosarcoma cell lines
por: Zhang, Shuwei, et al.
Publicado: (2018)

Mechanical stretch induces Ca(2+) influx and extracellular release of PGE(2) through Piezo1 activation in trabecular meshwork cells
por: Uchida, Takatoshi, et al.
Publicado: (2021)

Targeted Delivery of siRNA Therapeutics to Malignant Tumors
por: Leng, Qixin, et al.
Publicado: (2017)

Stimulation of Piezo1 by mechanical signals promotes bone anabolism
por: Li, Xuehua, et al.
Publicado: (2019)

Morphological, Immunocytochemical, and Biochemical Studies of Rat Costal Chondrocytes Exposed to IL-1β and TGF-β1
por: Li, Xiaoli, et al.
Publicado: (2017)

RNAi mechanisms in Huntington’s disease therapy: siRNA versus shRNA
por: Aguiar, Sebastian, et al.
Publicado: (2017)

siRNA Specificity: RNAi Mechanisms and Strategies to Reduce Off-Target Effects
por: Neumeier, Julia, et al.
Publicado: (2021)

The mechanisms of siRNA selection by plant Argonaute proteins triggering DNA methylation
por: Liu, Wei, et al.
Publicado: (2022)

PIEZO1 transduces mechanical itch in mice
por: Hill, Rose Z., et al.
Publicado: (2022)

Predicting siRNA efficacy based on multiple selective siRNA representations and their combination at score level
por: He, Fei, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_n7epqhvhc9j31jbcv1vq14vfpd