Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity

The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembr...

Descripción completa

Detalles Bibliográficos
Autores principales: Yao, Annie Y., Yan, Riqiang
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Commentary
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661164/
https://www.ncbi.nlm.nih.gov/pubmed/33183335
http://dx.doi.org/10.1186/s13024-020-00417-0
_version_ 1783609155621224448
author Yao, Annie Y.
Yan, Riqiang
author_facet Yao, Annie Y.
Yan, Riqiang
author_sort Yao, Annie Y.
collection PubMed
description The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3.
format Online
Article
Text
id pubmed-7661164
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher BioMed Central
record_format MEDLINE/PubMed
spelling pubmed-76611642020-11-13 Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity Yao, Annie Y. Yan, Riqiang Mol Neurodegener Commentary The activity of γ-secretase is critical to the pathogenesis of Alzheimer’s disease (AD). How its activity is regulated is intriguing and highly important for any AD therapy that focuses on reduction of toxic amyloid peptides and amyloid deposition in patients. Recently, interferon-induced transmembrane protein 3 (IFITM3) has been identified as a novel regulator of γ-secretase through a specific interaction. This commentary highlights this exciting study and provides an updated link of γ-secretase activity to innate immunity through IFITM3. BioMed Central 2020-11-12 /pmc/articles/PMC7661164/ /pubmed/33183335 http://dx.doi.org/10.1186/s13024-020-00417-0 Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Commentary
Yao, Annie Y.
Yan, Riqiang
Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
title Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
title_full Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
title_fullStr Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
title_full_unstemmed Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
title_short Activity of Alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (IFITM) in innate immunity
title_sort activity of alzheimer’s γ-secretase is linked to changes of interferon-induced transmembrane proteins (ifitm) in innate immunity
topic Commentary
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661164/
https://www.ncbi.nlm.nih.gov/pubmed/33183335
http://dx.doi.org/10.1186/s13024-020-00417-0
work_keys_str_mv AT yaoanniey activityofalzheimersgsecretaseislinkedtochangesofinterferoninducedtransmembraneproteinsifitmininnateimmunity
AT yanriqiang activityofalzheimersgsecretaseislinkedtochangesofinterferoninducedtransmembraneproteinsifitmininnateimmunity

Ejemplares similares