Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus

The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and functioning of neuronal hippocampal networks throughout life. Here we show that leptin contro...

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Autores principales: Dumon, Camille, Belaidouni, Yasmine, Diabira, Diabe, Appleyard, Suzanne M., Wayman, Gary A., Gaiarsa, Jean-Luc
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Short Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661183/
https://www.ncbi.nlm.nih.gov/pubmed/33183317
http://dx.doi.org/10.1186/s13041-020-00689-z
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author Dumon, Camille
Belaidouni, Yasmine
Diabira, Diabe
Appleyard, Suzanne M.
Wayman, Gary A.
Gaiarsa, Jean-Luc
author_facet Dumon, Camille
Belaidouni, Yasmine
Diabira, Diabe
Appleyard, Suzanne M.
Wayman, Gary A.
Gaiarsa, Jean-Luc
author_sort Dumon, Camille
collection PubMed
description The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and functioning of neuronal hippocampal networks throughout life. Here we show that leptin controls chloride homeostasis in the developing rat hippocampus in vitro. The effect of leptin relies on the down-regulation of the potassium/chloride extruder KCC2 activity and is present during a restricted period of postnatal development. This study confirms and extends the role of leptin in the ontogenesis of functional GABAergic inhibition and helps understanding how abnormal levels of leptin may contribute to neurological disorders.
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spelling pubmed-76611832020-11-13 Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus Dumon, Camille Belaidouni, Yasmine Diabira, Diabe Appleyard, Suzanne M. Wayman, Gary A. Gaiarsa, Jean-Luc Mol Brain Short Report The canonical physiological role of leptin is to regulate hunger and satiety acting on specific hypothalamic nuclei. Beyond this key metabolic function; leptin also regulates many aspects of development and functioning of neuronal hippocampal networks throughout life. Here we show that leptin controls chloride homeostasis in the developing rat hippocampus in vitro. The effect of leptin relies on the down-regulation of the potassium/chloride extruder KCC2 activity and is present during a restricted period of postnatal development. This study confirms and extends the role of leptin in the ontogenesis of functional GABAergic inhibition and helps understanding how abnormal levels of leptin may contribute to neurological disorders. BioMed Central 2020-11-12 /pmc/articles/PMC7661183/ /pubmed/33183317 http://dx.doi.org/10.1186/s13041-020-00689-z Text en © The Author(s) 2020 Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data.
spellingShingle Short Report
Dumon, Camille
Belaidouni, Yasmine
Diabira, Diabe
Appleyard, Suzanne M.
Wayman, Gary A.
Gaiarsa, Jean-Luc
Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
title Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
title_full Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
title_fullStr Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
title_full_unstemmed Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
title_short Leptin down-regulates KCC2 activity and controls chloride homeostasis in the neonatal rat hippocampus
title_sort leptin down-regulates kcc2 activity and controls chloride homeostasis in the neonatal rat hippocampus
topic Short Report
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661183/
https://www.ncbi.nlm.nih.gov/pubmed/33183317
http://dx.doi.org/10.1186/s13041-020-00689-z
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