Flucloxacillin decreases tacrolimus blood trough levels: a single-center retrospective cohort study

PURPOSE: Tacrolimus and everolimus are widely used to prevent allograft rejection. Both are metabolized by the hepatic cytochrome P450 (CYP) enzyme CYP3A4 and are substrate for P-glycoprotein (P-gp). Drugs influencing the activity or expression of CYP enzymes and P-gp can cause clinically relevant c...

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Detalles Bibliográficos
Autores principales: Veenhof, Herman, Schouw, Hugo M., Besouw, Martine T. P., Touw, Daan J., Gracchi, Valentina
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Pharmacokinetics and Disposition
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661399/
https://www.ncbi.nlm.nih.gov/pubmed/32712713
http://dx.doi.org/10.1007/s00228-020-02968-z

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661399/
https://www.ncbi.nlm.nih.gov/pubmed/32712713
http://dx.doi.org/10.1007/s00228-020-02968-z

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