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Evaluation of drug-drug interaction of lusutrombopag, a thrombopoietin receptor agonist, via metabolic enzymes and transporters

PURPOSE: Drug-drug interaction (DDI) potentials of lusutrombopag, a thrombopoietin receptor agonist, on the activity of cytochrome P450 (CYP) 3A and of cyclosporine, which inhibits P-glycoprotein and breast cancer resistance protein, on lusutrombopag pharmacokinetics were assessed via clinical studi...

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Detalles Bibliográficos
Autores principales:	Katsube, Takayuki, Inoue, Yuji, Fukuhara, Takahiro, Kano, Takeshi, Wajima, Toshihiro
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Springer Berlin Heidelberg 2020
Materias:	Pharmacokinetics and Disposition
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661413/ https://www.ncbi.nlm.nih.gov/pubmed/32666123 http://dx.doi.org/10.1007/s00228-020-02960-7

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