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Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany

PURPOSE: Chronic pain is common in the older population and a significant public health concern. However, comprehensive studies on analgesics use in this age group from Germany are scarce. This study aims to give a comprehensive overview on the use of the most common therapeutic groups of analgesics...

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Autores principales: Nguyen, Thi Ngoc Mai, Laetsch, Dana Clarissa, Chen, Li-Ju, Haefeli, Walter Emil, Meid, Andreas D, Brenner, Hermann, Schöttker, Ben
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer Berlin Heidelberg 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661425/
https://www.ncbi.nlm.nih.gov/pubmed/32648116
http://dx.doi.org/10.1007/s00228-020-02954-5
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author Nguyen, Thi Ngoc Mai
Laetsch, Dana Clarissa
Chen, Li-Ju
Haefeli, Walter Emil
Meid, Andreas D
Brenner, Hermann
Schöttker, Ben
author_facet Nguyen, Thi Ngoc Mai
Laetsch, Dana Clarissa
Chen, Li-Ju
Haefeli, Walter Emil
Meid, Andreas D
Brenner, Hermann
Schöttker, Ben
author_sort Nguyen, Thi Ngoc Mai
collection PubMed
description PURPOSE: Chronic pain is common in the older population and a significant public health concern. However, comprehensive studies on analgesics use in this age group from Germany are scarce. This study aims to give a comprehensive overview on the use of the most common therapeutic groups of analgesics in community-dwelling older adults from Germany. METHODS: A cross-sectional study was carried out using data from a German cohort of 2038 community-dwelling adults aged 63–89 years. Descriptive statistics and logistic regression models were applied to assess the utilization of analgesics by age, sex, pain severity, pain duration, and locations. RESULTS: One out of four study participants was suffering from high-intensity or disabling pain. Approximately half of those taking analgesics still reported to suffer from high-intensity or disabling pain. Among analgesics users, occasional non-steroidal anti-inflammatory drugs (NSAIDs) use was the most frequent pain therapy (in 43.6% of users), followed by metamizole (dipyrone) use (16.1%), regular NSAIDs use (12.9%), strong opioids use (12.7%), and weak opioids use (12.0%). In multivariate logistic regression models, higher age, higher pain severity, longer pain duration, abdominal pain, and back pain were statistically significantly associated with opioids use. Metamizole use was also statistically significantly associated with higher pain severity but inversely associated with pain duration. CONCLUSIONS: A significant number of older German adults are affected by high-intensity and disabling chronic pain despite receiving analgesics. Long-term studies are needed to compare the effectiveness and safety of different treatments for chronic pain in older adults. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00228-020-02954-5) contains supplementary material, which is available to authorized users.
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spelling pubmed-76614252020-11-13 Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany Nguyen, Thi Ngoc Mai Laetsch, Dana Clarissa Chen, Li-Ju Haefeli, Walter Emil Meid, Andreas D Brenner, Hermann Schöttker, Ben Eur J Clin Pharmacol Pharmacoepidemiology and Prescription PURPOSE: Chronic pain is common in the older population and a significant public health concern. However, comprehensive studies on analgesics use in this age group from Germany are scarce. This study aims to give a comprehensive overview on the use of the most common therapeutic groups of analgesics in community-dwelling older adults from Germany. METHODS: A cross-sectional study was carried out using data from a German cohort of 2038 community-dwelling adults aged 63–89 years. Descriptive statistics and logistic regression models were applied to assess the utilization of analgesics by age, sex, pain severity, pain duration, and locations. RESULTS: One out of four study participants was suffering from high-intensity or disabling pain. Approximately half of those taking analgesics still reported to suffer from high-intensity or disabling pain. Among analgesics users, occasional non-steroidal anti-inflammatory drugs (NSAIDs) use was the most frequent pain therapy (in 43.6% of users), followed by metamizole (dipyrone) use (16.1%), regular NSAIDs use (12.9%), strong opioids use (12.7%), and weak opioids use (12.0%). In multivariate logistic regression models, higher age, higher pain severity, longer pain duration, abdominal pain, and back pain were statistically significantly associated with opioids use. Metamizole use was also statistically significantly associated with higher pain severity but inversely associated with pain duration. CONCLUSIONS: A significant number of older German adults are affected by high-intensity and disabling chronic pain despite receiving analgesics. Long-term studies are needed to compare the effectiveness and safety of different treatments for chronic pain in older adults. ELECTRONIC SUPPLEMENTARY MATERIAL: The online version of this article (10.1007/s00228-020-02954-5) contains supplementary material, which is available to authorized users. Springer Berlin Heidelberg 2020-07-10 2020 /pmc/articles/PMC7661425/ /pubmed/32648116 http://dx.doi.org/10.1007/s00228-020-02954-5 Text en © The Author(s) 2020 Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.
spellingShingle Pharmacoepidemiology and Prescription
Nguyen, Thi Ngoc Mai
Laetsch, Dana Clarissa
Chen, Li-Ju
Haefeli, Walter Emil
Meid, Andreas D
Brenner, Hermann
Schöttker, Ben
Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany
title Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany
title_full Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany
title_fullStr Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany
title_full_unstemmed Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany
title_short Pain severity and analgesics use in the community-dwelling older population: a drug utilization study from Germany
title_sort pain severity and analgesics use in the community-dwelling older population: a drug utilization study from germany
topic Pharmacoepidemiology and Prescription
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661425/
https://www.ncbi.nlm.nih.gov/pubmed/32648116
http://dx.doi.org/10.1007/s00228-020-02954-5
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