Engineering of α-PD-1 antibody-expressing long-lived plasma cells by CRISPR/Cas9-mediated targeted gene integration

Long-lived plasma cells (LLPCs) are robust specialized antibody-secreting cells that mainly stay in the bone marrow and can persist a lifetime. As they can be generated by inducing the differentiation of B-lymphocytes, we investigated the possibility that human LLPCs might be engineered to express α...

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Detalles Bibliográficos
Autores principales: Luo, Baohong, Zhan, Yikang, Luo, Minqi, Dong, Huimin, Liu, Jun, Lin, Yingtong, Zhang, Junsong, Wang, Guanwen, Verhoeyen, Els, Zhang, Yiwen, Zhang, Hui
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7661525/
https://www.ncbi.nlm.nih.gov/pubmed/33184267
http://dx.doi.org/10.1038/s41419-020-03187-1

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